Predicting Fragilty Fractures Using Hip Radiographs
使用髋部射线照片预测脆性骨折
基本信息
- 批准号:6936712
- 负责人:
- 金额:$ 39.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-05 至 2007-08-31
- 项目状态:已结题
- 来源:
- 关键词:X raybiomechanicsbone densityclinical researchclinical trialscomputer data analysiscomputer program /softwarediagnosis design /evaluationdiagnosis quality /standarddigital imagingdisease /disorder proneness /riskhip fractureshuman subjectimage processinginjury preventionmedical complicationmorphologymusculoskeletal disorder diagnosisnoninvasive diagnosisosteoporosispatient oriented researchphoton absorptiometrysubstantia spongiosawomen&aposs health
项目摘要
DESCRIPTION (provided by applicant): Hip fracture is the most serious consequence of osteoporosis. In 2002, the cost of treating hip fractures consumed 63% of the national direct expenditure for OP, or more than $10 billion. By 2050, due to a rapidly aging population, the annual cost of treating hip fractures is projected to increase 6 fold to more than $60 billion. The ability to accurately estimate an individual's risk of osteoporotic hip fracture is key in preventing the expected increase of hip fractures because it would identify those individuals needing the most potent available fracture reduction therapy. Bone Mineral Density (BMD) measurement is currently used for diagnosis of osteoporosis. However, it has only limited utility in predicting hip fracture. This is because Individual fracture risk is also strongly influenced by local bone architecture and structure, bone turnover, cortical thickness, and, fall biomechanics. We recently developed (SBIR Phase 1) non-invasive automated imaging technology using ordinary radiographs that can measure cortical and trabecular parameters that are comparable to those measured by 3D uCT. In general it involves x-ray digitization, identification of regions of interest, trabecular extraction, background subtraction to obtain an image of trabecular structures and binerization plus skeletonization of those structures. Parameters of trabecular structure are measured using algorithms. 2D measurements of trabecular structure in ordinary radiographs of cores of proximal cadaveric femora correlated well with 3D mu/CT measurements. Those 2D measurements also correlated with biomechanical failure loads applied to those cores as well to whole cadaver proximal femora(J Bone Min Res 2003 ;18 Suppl 2, Abst # 1218, J Bone Min Res; 18 Suppl 2 Abst # 107 2003.). Our hypotheses in this proposal are: targeted, focal assessment of bone structure in hip x-ravs yields vastly improved ability to predict osteoporotic fracture as compared with BMD measurements. To assess the validity of this hypothesis, we will determine if the technology developed in Phase I of this project has the ability to discriminate between healthy postmenopausal women and postmenopausal women who have retrospectively experienced osteoporotic fractures. We will also test the short term reproducibility in vivo of our x-ray based measurements of bone microstructure and bone geometry by measuring them twice in those same groups no more than two weeks apart as the root mean square of the individual reproducibility errors.
描述(由申请人提供):髋部骨折是骨质疏松症的最严重结果。 2002年,治疗髋部骨折的成本消耗了全国直接支出的63%的OP,或超过100亿美元。到2050年,由于人口迅速老龄化,治疗髋部骨折的年成本预计将增加6倍至600亿美元以上。准确估计个人患骨质疏松性髋部骨折的风险的能力是防止髋部骨折的预期增加,因为它将确定那些需要最有效的可用骨折疗法的人。目前,骨矿物质密度(BMD)测量用于诊断骨质疏松症。但是,它在预测髋部骨折方面只有有限的效用。这是因为单个骨折风险也受到局部骨结构和结构,骨骼更新,皮质厚度以及秋季生物力学的强烈影响。我们最近使用普通的X光片开发了(SBIR阶段1)非侵入性自动成像技术,这些射线照相可以测量与3D UCT测量的皮质和小梁参数。通常,它涉及X射线数字化,目标区域的鉴定,小梁提取,背景减法,以获得小梁结构的图像和脱衣化以及这些结构的骨骼化。小梁结构的参数是使用算法测量的。近端尸体股骨核心岩心片的小梁结构的2D测量与3D MU/CT测量良好相关。这些2D测量也与对这些核心施加的生物力学失效负荷以及整个尸体近端股骨相关(J Bone Min Res 2003; 18 Suppl 2,Abst#1218,J Bone Min Res; J Bone Min Res; 18 Suppl 2 Abst#107 2003年。)。我们在该提案中的假设是:与BMD测量值相比,对髋X-RAV中骨骼结构的焦点评估具有大大提高的预测骨质疏松性骨折的能力。为了评估该假设的有效性,我们将确定该项目I期在该项目的第一阶段开发的技术是否能够区分健康的绝经后妇女和绝经后妇女,这些妇女回顾性地经历了骨质疏松性骨折。我们还将通过与单个可重复性误差相距不超过两周的相同根平方的相同根平方来测量两次,从而测量基于X射线的骨微结构和骨几何形状的短期可重复性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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{{ truncateString('CLAUDE D ARNAUD', 18)}}的其他基金
Preventing Osteoporotic Hip Fractures by Accurately Predicting Future Fractures
通过准确预测未来骨折来预防骨质疏松性髋部骨折
- 批准号:
7053955 - 财政年份:2006
- 资助金额:
$ 39.9万 - 项目类别:
Predicting Fragilty Fractures Using Hip Radiographs
使用髋部射线照片预测脆性骨折
- 批准号:
7120099 - 财政年份:2005
- 资助金额:
$ 39.9万 - 项目类别:
Hip Radiographs: Novel Method to Diagnose Osteoporosis
髋关节X光片:诊断骨质疏松症的新方法
- 批准号:
6693883 - 财政年份:2003
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
2764151 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
2052145 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
2052146 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
3122885 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
2429277 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
BUILDING BONE IN OSTEOPOROSIS WITH PTH AND ESTROGEN
用 PTH 和雌激素增强骨质疏松症的骨质
- 批准号:
2712126 - 财政年份:1993
- 资助金额:
$ 39.9万 - 项目类别:
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