Hip Radiographs: Novel Method to Diagnose Osteoporosis

髋关节X光片：诊断骨质疏松症的新方法

• 批准号: 6693883
• 负责人: CLAUDE D ARNAUD
• 金额: $ 15.51万
• 依托单位: IMAGING THERAPEUTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693883
• 关键词: X ray; bioimaging /biomedical imaging; biomedical automation; bone density; bone imaging /visualization /scanning; diagnosis design /evaluation; disease /disorder proneness /risk; hip; hip fractures; image processing; musculoskeletal disorder diagnosis; osteoporosis; pathologic process; radiodiagnosis; structural biology; substantia spongiosa

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop techniques for the diagnosis of osteoporosis and for assessing fracture risk by quantifying trabecular structural elements in hip x-rays. Osteoporosis is a public health threat for 44 million women in the United States alone. The inability to identify persons at risk for the disease is a major impediment in dealing with this epidemic. In fact, less than 30% of persons with osteoporosis are aware that they have it. This is due to the high cost and resulting small installed base of commercially available osteoporosis testing systems. Imaging Therapeutics Inc. proposes to develop technology for low-cost bone structural analyses by linking readily available x-ray equipment to novel image analysis algorithms. While measurements of bone mineral density (BMD) are easy to perform and are helpful in determining when to intervene therapeutically, low BMD accounts for only a portion of fracture risk. Progressive disruption of trabecular structure contributes the better part of the remainder of that risk. The aims of this proposal are: 1) To develop new image processing techniques for automated measurement of 2D-trabecular bone structural elements in hip radiographs. 2) To determine the influence of x-ray beam angulation, soft-tissue attenuation and radiographic technique on radiographic measurements of bone structure. 3) To determine the clinical validity of those 2 D measurements in vitro by a) comparing them, in cores of cadaver proximal femora, to similar measurements made using 3D micro CT and b) determining if they correlate significantly with biomechanical failure loads and stiffness. 4) To directly apply the technology developed in Phase I of this proposal to a series of clinical trials that will be developed for Phase II to prove the clinical utility of that technology in the diagnosis of osteoporosis and prediction of osteoporotic fracture.

描述（由申请人提供）：该小型企业创新研究第一阶段项目旨在开发诊断骨质疏松症的技术，并通过量化髋部 X 射线中的小梁结构元素来评估骨折风险。仅在美国，骨质疏松症就对 4400 万女性构成公共卫生威胁。无法识别有感染该疾病风险的人是应对这一流行病的主要障碍。事实上，只有不到 30% 的骨质疏松症患者知道自己患有骨质疏松症。这是由于商用骨质疏松症测试系统成本高且安装基数小。 Imaging Therapeutics Inc. 提议通过将现成的 X 射线设备与新颖的图像分析算法联系起来，开发低成本骨结构分析技术。虽然骨矿物质密度 (BMD) 的测量很容易进行，并且有助于确定何时进行治疗干预，但低 BMD 只能解释部分骨折风险。小梁结构的逐渐破坏造成了其余风险的大部分。该提案的目的是：1）开发新的图像处理技术，用于自动测量髋部放射照片中的二维小梁骨结构元素。 2) 确定X射线束角度、软组织衰减和射线照相技术对骨结构射线照相测量的影响。 3) 通过 a) 将尸体近端股骨核心中的 2D 测量值与使用 3D 显微 CT 进行的类似测量值进行比较，以及 b) 确定它们是否与生物力学失效载荷和刚度显着相关，从而确定体外这些 2D 测量值的临床有效性。 4）将本提案一期开发的技术直接应用到二期开发的一系列临床试验中，以证明该技术在骨质疏松诊断和骨质疏松性骨折预测方面的临床实用性。

项目成果

Radiographic trabecular 2D and 3D parameters of proximal femoral bone cores correlate with each other and with yield stress.

• DOI: 10.1007/s00198-009-0908-z
• 发表时间: 2009-11
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Steines, D.;Liew, S. -W.;Arnaud, C.;Vargas-Voracek, R.;Nazarian, A.;Mueller, R.;Snyder, B.;Hess, P.;Lang, P.
• 通讯作者: Lang, P.