Neuroendocrine Factors in Adolescent Obesity

青少年肥胖的神经内分泌因素

• 批准号: 6994904
• 负责人: Patrika M Tsai
• 金额: $ 5.35万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6994904
• 关键词: adolescence (12-20); appetite; blood chemistry; body composition; clinical research; dietary constituent; epidemiology; female; ghrelin; hormone regulation /control mechanism; human subject; insulin sensitivity /resistance; magnetic resonance imaging; nutrition related tag; obesity; photon absorptiometry; postdoctoral investigator; somatotropin

DESCRIPTION (provided by applicant): Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH), and insulin, which have not been examined in the adolescent age group. Ghrelin, a primarily gastric hormone, increases appetite and is a GH secretagogue. This study will compare the alteration in secretion of ghrelin and GH in overweight and normal weight adolescent girls through frequent blood sampling and GH stimulation testing with growth hormone releasing hormone and arginine. The relationship between these hormones and insulin resistance, measured by 1H-nuclear magnetic resonance spectroscopy, and body composition, measured by dual energy x-ray absorptiometry and magnetic resonance imaging, will be investigated. This study will also determine the postprandial ghrelin response to test meals that vary by the type of predominant macronutrient, which may predict the degree of hunger and amount of intake at a subsequent meal. Understanding obesity-related changes in ghrelin and GH and their relationship to body composition, insulin resistance, and appetite will help in the development of strategies to reduce complications of obesity.

描述（由申请人提供）：肥胖是一种流行病，它比以往任何时候都更年轻。肥胖与几种激素的分泌模式的变化有关，包括生长素素，生长激素（GH）和胰岛素，这些激素尚未在青少年年龄组中进行检查。 Ghrelin是一种主要是胃激素，可以增加食欲，并且是GH的秘密。这项研究将通过频繁的血液采样和GH刺激测试与生长激素释放激素和精氨酸来比较超重和正常体重青春期女孩在超重和正常体重青春期女孩中分泌的改变。这些激素与胰岛素耐药性通过1H核磁共振光谱和人体组成（通过双能X射线吸收仪和磁共振成像测量）之间的关系。这项研究还将确定餐后生长素素对测试餐的反应，这些反应因主要的大量营养素的类型而异，这可能预测随后的餐食中的饥饿程度和摄入量的程度。了解与肥胖相关的变化蛋白和GH的变化及其与身体成分，胰岛素抵抗和食欲的关系将有助于制定减少肥胖并发症的策略。