Sleep Apnea in Children with Craniofacial Anomalies

颅面异常儿童的睡眠呼吸暂停

• 批准号: 7052987
• 负责人: Derek J Lam
• 金额: $ 4.69万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-08 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052987
• 关键词: age difference; children; clinical research; congenital oral /facial /cranial defect; data collection methodology /evaluation; diagnosis; disease /disorder proneness /risk; epidemiology; human subject; polysomnography; questionnaires; racial /ethnic difference; respiratory disorder diagnosis; sign /symptom; sleep apnea

DESCRIPTION (provided by applicant): Craniofacial abnormalities frequently result in upper airway compromise and thus appear to be predisposing factors for the development of obstructive sleep apnea. However, no estimates of the prevalence of sleep apnea in the pediatric craniofacial clinic population have been reported. The objectives of this research are to estimate the prevalence of sleep apnea in this population and identify risk factors for diagnosis by polysomnography in a prospective observational cohort study of this population. A secondary objective is to validate the Pediatric Sleep Questionnaire (PSQ) as a screening tool in the craniofacial population. Long term objectives include validating sleep apnea quality of life outcome measures in this population and evaluating longitudinal natural history and treatment outcomes. Multivariate regression analysis will be used to quantify risk factors including age, race, symptoms, and craniofacial diagnosis. Criterion validity of the PSQ will be assessed by comparison with polysomnography results in a subset of the cohort. This study will allow better identification of children in the craniofacial clinic population who are most at risk for developing sleep apnea and inform the decision-making process for evaluation and treatment.

描述（由申请人提供）：颅面异常经常导致上呼吸道妥协，因此似乎是阻塞性睡眠呼吸暂停发展的诱发因素。然而，尚未估计小儿颅面诊所人群中睡眠呼吸暂停的患病率。这项研究的目的是估计该人群中睡眠呼吸暂停的流行率，并在对该人群的前瞻性观察队列研究中确定通过多聚会术诊断的危险因素。次要目标是将小儿睡眠问卷（PSQ）验证为颅面种群中的筛查工具。长期目标包括验证该人群中的睡眠呼吸暂停质量结果测量指标以及评估纵向自然历史和治疗结果。多元回归分析将用于量化风险因素，包括年龄，种族，症状和颅面诊断。 PSQ的标准有效性将通过与多个多摄影的比较评估，从而导致一部分。这项研究将允许在颅面诊所人群中更好地识别儿童，这些儿童面临着患睡眠呼吸暂停的风险，并为评估和治疗的决策过程提供了信息。