Diabetes Mellitus:Molecular Signaling,Genes/Therapeutics

糖尿病：分子信号、基因/治疗

基本信息

批准号：
6747803
负责人：
MICHAEL P CZECH
金额：
$ 2万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-03-03 至 2005-03-02
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The current worldwide epidemic of Diabetes Mellitus has fueled intensive efforts to understand the basic genetic and molecular mechanisms of cell signaling in a variety of relevant tissues. These research efforts by both basic and clinical researchers have successfully utilized the technologies of genomics, proteomics and chemical biology as well as the traditional tools of genetics, physiology and molecular and cell biology to yield exciting new insights into this disease. Particularly novel findings relate to the interface between insulin signaling and membrane trafficking; beta cell development and apoptosis; adipocyte signaling to brain, beta cells, liver and muscle; and the role of cytokines in insulin resistance. The goal of the conference (to be held jointly with the Molecular Control of Adipogenesis and Obesity conference organized by Stephen Farmer and Sheila Collins) will be to bring together scientists working in several intersecting areas of the field, e.g., the application of new technologies to diabetes; stem cell and developmental biology; regulated membrane trafficking; integration of metabolism and gene expression; and chemistry and therapeutics. The conference will also explore the integration and utility of information derived from recently obtained gene and protein databases, as well as repositories of protein-protein interactions. Half of the sessions will be jointly held with the concurrent meeting on adipogenesis in order to optimize the information flow between researchers in the fields of the related syndromes of diabetes and obesity. This meeting format is unique among other meetings in these fields, and provides the vehicle for fertile and critical interactions between basic and physician scientists. Confirmation of this meeting's unique catalytic role is reflected in the large number of outstanding scientists who attended the last such conference in 2002. Great effort is expended on assuring that both speakers and attendees include high representation of women and minority scientists. It should also be noted that since this last meeting only a little more than a year ago, dramatic advances in the field have been made and published. Such advances include the generation of novel gene-ablated and transgenic mouse models and new understanding of the role of peptides secreted by adipocytes that act on muscle and liver to control integrated whole body metabolism and glucose tolerance. Further, the discovery of novel cellular proteins that act on processes that regulate glucose transporters and other metabolic parameters to control glucose homeostasis have been dramatic. The proposed meeting is therefore very timely and poised to make an important contribution to the field by fostering unique collaborative interactions between basic and physician scientists.

描述（由申请人提供）：当前糖尿病在全球范围内的流行促使人们大力了解各种相关组织中细胞信号传导的基本遗传和分子机制。基础和临床研究人员的这些研究工作成功地利用了基因组学、蛋白质组学和化学生物学技术以及遗传学、生理学、分子和细胞生物学的传统工具，对这种疾病产生了令人兴奋的新见解。特别新颖的发现涉及胰岛素信号传导和膜运输之间的界面； β细胞发育和凋亡；脂肪细胞向大脑、β细胞、肝脏和肌肉发出信号；以及细胞因子在胰岛素抵抗中的作用。这次会议（将与斯蒂芬·法默和希拉·柯林斯组织的脂肪生成和肥胖分子控制会议联合举行）的目标是将在该领域几个交叉领域工作的科学家聚集在一起，例如新技术的应用糖尿病;干细胞和发育生物学；受监管的膜运输；新陈代谢和基因表达的整合；以及化学和治疗学。会议还将探讨从最近获得的基因和蛋白质数据库以及蛋白质-蛋白质相互作用存储库中获得的信息的整合和利用。一半的会议将与同时举行的脂肪生成会议联合举行，以优化糖尿病和肥胖相关综合征领域研究人员之间的信息流。这种会议形式在这些领域的其他会议中是独一无二的，为基础科学家和医学科学家之间的丰富和关键的互动提供了工具。这次会议独特的催化作用体现在出席 2002 年上一次此类会议的众多杰出科学家上。我们付出了巨大努力，确保发言者和与会者中女性和少数族裔科学家的比例较高。还应该指出的是，自上次会议仅一年多前以来，该领域已经取得并发表了巨大的进展。这些进步包括产生新的基因消除和转基因小鼠模型，以及对脂肪细胞分泌的肽作用的新认识，这些肽作用于肌肉和肝脏以控制整体全身代谢和葡萄糖耐量。此外，作用于调节葡萄糖转运蛋白和其他代谢参数以控制葡萄糖稳态的过程的新型细胞蛋白的发现是引人注目的。因此，拟议的会议非常及时，并将通过促进基础科学家和医学科学家之间独特的合作互动，为该领域做出重要贡献。