Genome Sequence Variation

基因组序列变异

• 批准号: 7058579
• 负责人: David Altshuler
• 金额: $ 1.2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058579
• 关键词: family genetics; functional /structural genomics; genetic susceptibility; human population genetics; meeting /conference /symposium; method development; travel

DESCRIPTION (provided by applicant): Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible for the first time to perform well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characteristics, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives. The root causes of most common human diseases remains unknown, with one of our most promising clues to causation being the familial clustering of disease. Leveraging information from the human genome projects, genetic epidemiology, quantitative and population genetics, it is increasingly practical to find the genetic determinants of common diseases. By bringing together leading investigators in each of these disciplines, this meeting will lead to improved methods to discover genetic contributors to disease, which will in turn improve the effectiveness and safety of interventions used to improve public health.

描述（由申请人提供）：常见的人类疾病和大多数其他特征以连续的方式变化，被多种基因和环境影响所修改。关于基因组序列变化的快速扩展的信息使得首次有可能对常见疾病和其他复杂表型的遗传贡献进行良好的搜索。成功将为定量特征的遗传结构，特质变异的进化史以及常见人类疾病的病因提供洞察力。这次会议旨在将调查人员从人口遗传学，基因组学，定量遗传学，流行病学和医学研究中汇集在一起​​，以从各种角度研究这些问题。 最常见的人类疾病的根本原因仍然未知，我们最有前途的因果关系之一是疾病的家族性聚类。利用人类基因组项目，遗传流行病学，定量和人群遗传学的信息，找到常见疾病的遗传决定因素越来越实用。通过将每个学科的领先研究人员汇集在一起​​，这次会议将改善发现疾病遗传因素的方法，这反过来又可以提高用于改善公共卫生的干预措施的有效性和安全性。