Connective Tissues as a Factor in Vocal Fold Paralysis

结缔组织是声带麻痹的一个因素

• 批准号: 6938552
• 负责人: Julie M Barkmeier-Kraemer
• 金额: $ 18.94万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6938552
• 关键词: adipose tissue; age difference; blood circulation; collagen; dogs; gender difference; histology; human old age (65+); human tissue; ischemia; laryngeal nerves; microcirculation; morphology; nerve injury; paralysis; postmortem; species difference; vagus nerve; vocal cords; young adult human (21-34)

DESCRIPTION (provided by applicant): The goal of this research is to investigate the "packaging" and the vascular supply to the recurrent laryngeal branch (RLN) of the vagus nerve as factors in the onset of unilateral vocal fold paralysis (UVP). The vocal folds are important for protection of the airway during swallowing and for generating voice. Individuals with UVP, therefore, frequently experience choking while eating and difficulty being heard when speaking. The occurrence of UVP increases with age, occurs more frequently on the left side, and is most often associated with surgical injury, tumor mass, and viral infection that impairs RLN function. In approximately l6-3l percent of all UVP cases, onset of paralysis is idiopathic. The research proposed in this application will address possible connective tissue factors that may explain UVP, particularly in individuals with idiopathic and post-surgical etiologies. Specifically, this research will characterize size and makeup of the "packaging," or epineurium, surrounding RLN nerve fascicles in young and senescent adult human cadavers and make comparisons to previous findings from research using dogs. This research also will characterize the vascular supply to the RLN in humans. Knowledge gained from this research will provide insight into the predisposition of the RLN to ischemia during compression or stretching. Findings from this research may lead to new surgical approaches to protect the RLN from damage during procedures affecting the pharynx, trachea, thyroid gland, esophagus, lungs, and heart. In addition, identification of age-related differences in the protective nerve "packaging" and vascular supply may elucidate tissue factors possibly associated with onset of idiopathic UVP for future anatomic and physiologic investigation using an animal model.

描述（由申请人提供）：这项研究的目的是 研究“包装”和对复发性喉的血管供应 迷走神经的分支（RLN）作为单侧声带发作的因素 折叠麻痹（UVP）。声带对于保护 吞咽期间的气道和发出声音。患有UVP的人， 因此，经常在进食和困难时经常经历窒息 说话时听到。 UVP的发生随着年龄的增长而增加，发生更多 经常在左侧，通常与手术损伤有关， 肿瘤肿块和病毒感染会损害RLN功能。大约 在所有UVP病例中，L6-3L％瘫痪是特发性的。研究 在此应用中提出的将解决可能的结缔组织因子 这可能解释了UVP，特别是在特发性和 后手术病因。具体而言，这项研究将表征大小 和“包装”或Epineurium的构成，周围RLN神经束 在年轻和衰老的成人人类尸体中，并与以前进行比较 研究的发现使用狗。这项研究还将表征 人类RLN的血管供应。从这项研究中获得的知识将 在RLN对缺血期间的易感性提供深入了解 压缩或拉伸。这项研究的发现可能导致新的手术 在影响该RLN的方法中保护RLN免受损坏的方法 咽，气管，甲状腺，食管，肺和心脏。此外， 保护神经“包装”中与年龄相关的差异的识别 血管供应可能阐明可能与发作有关的组织因素 特发性UVP的未来解剖学和生理研究 动物模型。