Development of APMS as a Chromatographic Substrate

APMS 作为色谱底物的开发

基本信息

批准号：
6885221
负责人：
CHRISTOPHER C LANDRY
金额：
$ 10万
依托单位：
APOLLO SRI, LLC
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-15 至 2007-03-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. These benefits are due to the physical properties of APMS, which consists of regular 5 um spheres with a surface area of 1100 m2/g. The proposed research has three main goals: (1) to initiate studies on larger-scale production of APMS; (2) to expand previous studies on chiral separations; and (3) to study the potential uses of APMS in size-exclusion chromatography. The ultimate goal of this research will be to produce a suite of HPLC column materials. The HPLC columns market is $500M and growing at 8% annually. Because HPLC is a standard research tool, successful commercialization of APMS will benefit society and researchers by accelerating the major advances in understanding fundamental life processes. In particular, APMS could facilitate liquid chromatography-mass spectrometry (LC-MS), size exclusion chromatography (SEC), and chiral separations.

描述（由申请人提供）：酸制备的介孔二氧化硅（“APMS”）在高效液相色谱（“HPLC”）（一种通常用于分离分子的技术）方面显示出比市售二氧化硅显着的进步。与商业 HPLC 色谱柱相比，含有 APMS 的 HPLC 色谱柱显着延长了分子保留时间并提高了峰间分辨率。这些优点归功于 APMS 的物理特性，它由表面积为 1100 m2/g 的规则 5 um 球体组成。拟议的研究有三个主要目标：（1）启动APMS大规模生产的研究； (2) 扩展先前关于手性分离的研究； (3) 研究 APMS 在尺寸排阻色谱中的潜在用途。这项研究的最终目标是生产一套 HPLC 色谱柱材料。 HPLC 色谱柱市场规模为 5 亿美元，并且每年以 8% 的速度增长。由于 HPLC 是一种标准研究工具，APMS 的成功商业化将加速理解基本生命过程的重大进展，从而造福社会和研究人员。特别是，APMS 可以促进液相色谱-质谱 (LC-MS)、尺寸排阻色谱 (SEC) 和手性分离。