Impact of Pesticide Exposure on Cognition in Children

接触农药对儿童认知的影响

• 批准号: 6754294
• 负责人: THOMAS V PETROS
• 金额: $ 14.02万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754294
• 关键词: academic achievement; agriculture worker; behavioral /social science research tag; blood toxicology; child psychology; cholinesterase inhibitors; clinical research; cognition; diet; environmental contamination; environmental exposure; environmental toxicology; human subject; intelligence tests; learning; lindane; memory; middle childhood (6-11); nutrition related tag; organophosphorus insecticide; pesticide biological effect; pesticide interaction; pesticides; psychomotor function; questionnaires; rural health

DESCRIPTION (provided by applicant): A number of previous studies have documented that exposure to cholinesterase-inhibiting pesticides such as organophosphates (OPS) and carbamates constitutes a major health problem. A number of studies have also examined the impact of OP poisoning and the impact of routine long-term exposure to pesticides in adults. The impact of long-term exposure to pesticides on children has been relatively unexplored. One objective of the proposed research is to examine the impact of chronic routine exposure to pesticides on cognitive and motor performance in children between 7 and 12 years of age. The specific areas tested will be memory performance, executive function performance, motor performance, and performance on school-related achievement tests. The proposed research will also measure concentrations of the pesticides (2, 4- dichlorophenoxyacetic acid) lindane and chloropyifos in the blood and urine in a sample of children between 7 and 12 years of age. These three pesticides are heavily applied in farming areas of the northeast quadrant of North Dakota where the participants will be recruited. In addition, blood will be assessed for concentrations of trace minerals and parents will complete a dietary intake questionnaire and the core food security module.

描述（由申请人提供）：许多先前的研究已经证明，接触胆碱酯酶抑制农药，例如有机磷酸酯（OPS）和氨基甲酸酯，会构成主要的健康问题。许多研究还研究了有机磷中毒的影响以及成人长期常规接触农药的影响。长期接触农药对儿童的影响相对尚未被研究。拟议研究的目标之一是调查长期接触农药对 7 至 12 岁儿童认知和运动表现的影响。测试的具体领域将是记忆表现、执行功能表现、运动表现以及学校相关成绩测试的表现。拟议的研究还将测量 7 至 12 岁儿童样本的血液和尿液中杀虫剂（2, 4-二氯苯氧基乙酸）林丹和毒死蜱的浓度。这三种农药在北达科他州东北象限的农业地区大量使用，参与者将在那里招募。此外，还将评估血液中微量矿物质的浓度，家长将完成膳食摄入调查问卷和核心食品安全模块。