Impact of Pesticide Exposure on Cognition in Children

接触农药对儿童认知的影响

• 批准号: 6754294
• 负责人: THOMAS V PETROS
• 金额: $ 14.02万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754294
• 关键词: academic achievement; agriculture worker; behavioral /social science research tag; blood toxicology; child psychology; cholinesterase inhibitors; clinical research; cognition; diet; environmental contamination; environmental exposure; environmental toxicology; human subject; intelligence tests; learning; lindane; memory; middle childhood (6-11); nutrition related tag; organophosphorus insecticide; pesticide biological effect; pesticide interaction; pesticides; psychomotor function; questionnaires; rural health

DESCRIPTION (provided by applicant): A number of previous studies have documented that exposure to cholinesterase-inhibiting pesticides such as organophosphates (OPS) and carbamates constitutes a major health problem. A number of studies have also examined the impact of OP poisoning and the impact of routine long-term exposure to pesticides in adults. The impact of long-term exposure to pesticides on children has been relatively unexplored. One objective of the proposed research is to examine the impact of chronic routine exposure to pesticides on cognitive and motor performance in children between 7 and 12 years of age. The specific areas tested will be memory performance, executive function performance, motor performance, and performance on school-related achievement tests. The proposed research will also measure concentrations of the pesticides (2, 4- dichlorophenoxyacetic acid) lindane and chloropyifos in the blood and urine in a sample of children between 7 and 12 years of age. These three pesticides are heavily applied in farming areas of the northeast quadrant of North Dakota where the participants will be recruited. In addition, blood will be assessed for concentrations of trace minerals and parents will complete a dietary intake questionnaire and the core food security module.

描述（由申请人提供）：许多先前的研究都证明，暴露于抑制胆碱酯酶的农药（例如有机磷酸盐（OPS）和氨基甲酸酯）和氨基甲酸酯是一个主要的健康问题。许多研究还研究了OP中毒的影响以及常规的长期暴露于成年人中的农药的影响。长期暴露于农药对儿童的影响相对尚未探索。拟议的研究的一个目的是检查慢性常规暴露于农药对7至12岁儿童认知和运动表现的影响。测试的特定领域将是与学校相关的成就测试中的记忆性能，执行功能性能，运动性能以及性能。拟议的研究还将在7至12岁的儿童样本中测量农药（2，4-二氯苯氧基乙酸）和叶绿素的浓度。这三种农药大量应用于北达科他州东北象限的农业区，将在那里招募参与者。此外，将评估血液矿物质的浓度，父母将填写饮食摄入问卷和核心食品安全模块。