A NEW APPROACH FOR BIOMEDICAL IMAGING

生物医学成像的新方法

• 批准号: 6530725
• 负责人: JAMES D WINEFORDNER
• 金额: $ 29.37万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530725
• 关键词: Raman spectrometry; adult human (21+); angiography; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biophysics; blood circulation; cardiovascular disorder; cesium; charge coupled device camera; electronic spectra; human subject; infrared spectrometry; interferometry; intravital microscopy; ionization; laser spectrometry; mercury; quantum chemistry; ultrasonography; ultrasound blood flow measurement; vapor

DESCRIPTION (Verbatim from the Applicant's Abstract): The goal of this research program is to develop an ultranarrowband imaging detector which can be used for in vivo biomedical imaging. The device will be capable of providing real time velocity information in images of arterial blood flow and compositional information via selective Raman imaging. Functioning in the near infrared, it will be capable of obtaining images at tissue depths of up to several cm. The extremely high spectral resolution is achieved by using an atomic vapor as the active sensing element. Laser pumped multi-step resonance ionization provides a near unity quantum efficiency and a large solid angle for optical collection, approaching 2m sr, is possible. When coupled with a microchannel plate amplification stage and a CCD detector, such devices offer unparalleled performance for specialized imaging applications. This research project will develop and optimize resonance ionization image devices using mercury and cesium as active elements. Studies will include the ionization spectroscopy of Hg and Cs, optimization of the detector response function (spectral bandwidth, quantum efficiency, spatial resolution), design and development of functional devices for imaging in biomedical systems and finally, applications to imaging of arterial blood flow in patients with peripheral vascular disease and the Raman imaging of arterial plaque.

描述（逐字摘自申请人摘要）：本研究的目标 计划是开发一种超窄带成像探测器，可用于 体内生物医学成像。该设备将能够提供实时 动脉血流和成分图像中的速度信息 通过选择性拉曼成像获取信息。它在近红外线下发挥作用， 将能够获得高达几厘米的组织深度的图像。这 通过使用原子蒸气作为光源，可以实现极高的光谱分辨率 有源传感元件。激光泵浦多步共振电离提供了 接近单位量子效率和用于光学收集的大立体角， 接近 2m sr 是可能的。与微通道板耦合时 放大级和 CCD 检测器，此类设备提供无与伦比的 专业成像应用的性能。该研究项目将 使用汞开发和优化共振电离成像装置 铯作为活性元素。研究将包括电离光谱 Hg 和 Cs，探测器响应函数的优化（光谱带宽、 量子效率，空间分辨率），功能设计和开发 生物医学系统中的成像设备以及最终的成像应用 周围血管疾病患者的动脉血流量 动脉斑块的拉曼成像。

项目成果

Laser-enhanced ionization with avalanche amplification: detection of cesium at fg/mL levels.

具有雪崩放大功能的激光增强电离：检测 fg/mL 水平的铯。

• 发表时间: 2003-07
• 影响因子: 3.5
• 作者: Temirov, J P;Matveev, O I;Smith, B W;Winefordner, J D
• 通讯作者: Winefordner, J D