Electrophoretic Nano-HA Coating for Improved Adhesion

电泳纳米 HA 涂层可提高附着力

• 批准号: 6805969
• 负责人: ZONGTAO ZHANG
• 金额: $ 14.7万
• 依托单位: INFRAMAT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805969
• 关键词: adhesions; biological models; biomaterial development /preparation; biomaterial interface interaction; bone prosthesis; cell differentiation; cell proliferation; corrosions; dental implants; dogs; electrophoresis; hydroxyapatites; joint prosthesis; medical implant science; nanotechnology; osteoblasts; surface coating

DESCRIPTION (provided by applicant): This proposed phase II program is expected to produce prototype hydroxyapatite ("HA") coated bone implants with significantly extended lifetime, fabricated using a room temperature electrophoretic deposition process. Novel HA nanocoatings with significantly increased adhesion strength and corrosion resistance under simulated body fluid in-vitro have been demonstrated in the Phase I work. The proposed Phase II program emphasizes developing prototype implant devices to rapidly commercialize this Phase I nanotechnology. The benefits of exceptional coating to substrate bond strength enable expansion of the HA nanocoatings market to hips, knees, and dental applications. Achieving 100% crystallinity and density at the HA substrate interface with electrophoretic deposited HA nanocoatings assures no degradation during implant service. Functionally graded HA nanocoatings can be generated at the HA tissue interface, thus promoting optimal bioactivity. The Phase II specific aims include scale up of the experimental HA bath nanocoating composition to pilot-scale production of prototype medical implants; demonstration of the HA nanoparticles coating on prototype medical implants, such as hip, knee, and dental implants; and demonstration of superior performance of the coated prototype devices with extended lifetime in-vivo, using an animal model. Phase II participants include Spire Corporation and the University of Texas at San Antonio.

描述（由申请人提供）：该提出的II期计划有望产生原型羟基磷灰石（“ HA”）涂层骨植入物，其寿命显着延长，并使用室温电泳沉积过程制造。在I期工作中已经证明了具有显着增加的HA纳米涂层，其粘附强度和耐腐蚀性显着增加。拟议的II期计划强调开发原型植入设备，以快速商业化该阶段I纳米技术。非凡涂层对基材债券强度的好处，可以扩大HA纳米涂料市场，从而扩大臀部，膝盖和牙科应用。通过电泳沉积的HA纳米涂料在HA基材界面上实现100％的结晶度和密度可确保植入期间不会降解。可以在HA组织界面上产生功能分级的HA纳米涂层，从而促进最佳生物活性。第二阶段的特定目的包括扩大实验性HA浴纳米含量的成分，以生产原型医疗植入物；在原型医学植入物（例如髋关节，膝盖和牙科植入物）上涂层的HA纳米颗粒的演示；以及使用动物模型的涂层原型设备具有延长寿命的涂层原型设备的出色性能。第二阶段的参与者包括尖顶公司和得克萨斯大学圣安东尼奥分校。