Childhood Precursors for Adulthood Metabolic Syndrome

成年代谢综合症的童年前兆

• 批准号: 6875951
• 负责人: SHUMEI S SUN
• 金额: $ 41.66万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875951
• 关键词: adolescence (12-20); biomarker; blood pressure; body composition; cardiovascular disorder risk; children; clinical research; diabetes risk; disease /disorder onset; disease /disorder proneness /risk; early diagnosis; early experience; gender difference; hemodynamics; human data; human puberty; human subject; insulin sensitivity /resistance; leptin; lipid metabolism; longitudinal human study; metabolic syndrome; metabolism disorder diagnosis; pathologic process; questionnaires

DESCRIPTION (provided by applicant): This grant application is a longitudinal cohort study submitted in response to the NIH Request for Applications, RFA-HD-03-033, "Establishing the Precursors of the Metabolic Syndrome in Children ". Our overall goal is to link the metabolic syndrome in adults [as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) to their childhood risk factors using long-term serial data collected from birth in 350 adult males and 348 adult females in the Fels Longitudinal Study. The ATP llI defines the metabolic syndrome in adults as having a cluster of three, four, or five risk factors that exceed criterion values, namely, waist circumference >102 cm for men and >88 cm for women; blood pressure >130/>85 mm Hg; plasma triglyceride level >150 mg/dL; plasma HDL-cholesterol level <40 mg/dL for men and <50mg/dL for women; and fasting plasma glucose >110 mg/dL. We propose (1) to determine if the onset of pathological values for any of the components of the metabolic syndrome begins in childhood; and, if so, to establish childhood criterion values for these biomarkers; (2) to examine in these 698 Fels adults changes and sexual dimorphism in values collected during their pubertal years for body fat, fat distribution, fat-free mass, lipid profiles, insulin resistance, blood pressure, leptin, adiponectin and C-reactive protein (CRP) in relation to the presence or absence of the metabolic syndrome in adulthood; and, (3) to relate adulthood changes in cardiac structure and hemodynamic parameters to contemporaneous changes in body fat, fat distribution, and fat-free mass and to metabolic syndrome over a three-year interval. We will conduct the proposed study using both the NCEP ATP III criterion of 110 mg/dL and the American Diabetes Association's (ADA) newly recommended criterion of 100 mg/dL for impaired fasting plasma glucose in order to elucidate the diagnostic implications of the lower threshold. Elucidating adverse relationships by linking childhood data to adult pathology may lead to the ability to detect children at elevated risk for the metabolic syndrome and, by implication, for type 2 diabetes mellitus and cardiovascular disease. The Fels long-term serial records provide a unique opportunity to accomplish our aims in an economical and efficient manner. Participants in the Fels Longitudinal Study are enrolled at birth and are not selected in regard to factors associated with any clinical condition. Consequently, the relationships revealed and the inferences drawn from the proposed study should reflect the natural history of the development of obesity, hypertension, dyslipidemia, and impaired glucose tolerance, and thus, should lead to the early identification of children at risk for the metabolic syndrome.

描述（由申请人提供）：该赠款申请是一项纵向队列研究，该研究是针对NIH申请请求RFA-HD-03-033提交的，“建立儿童代谢综合征的前体”。我们的总体目标是将成年人的代谢综合征（由国家胆固醇教育计划（NCEP）成人治疗小组III（ATP III）定义，使用350名成人男性和350名成人男性和348名成年女性纵向研究。 ATP LLI将成年人的代谢综合征定义为超过标准值的三个，四个或五个危险因素的簇，即男性的腰围> 102 cm，女性> 88 cm> 88 cm；血压> 130/> 85毫米汞柱；血浆甘油三酸酯水平> 150 mg/dl;男性血浆HDL-胆固醇水平<40 mg/dl，女性<50mg/dl；和禁食等离子体葡萄糖> 110 mg/dl。我们建议（1）确定代谢综合征任何成分的病理价值的发作是否始于童年。并且，如果是这样，为这些生物标志物建立童年标准价值； （2）在这698名fel中检查成年人在青春期收集的体内收集的值，脂肪分布，无脂肪质量，脂质谱，胰岛素抵抗，血压，血压，瘦素，脂连蛋白和C反应蛋白（CRP）与成年中的代谢综合征的存在或不存在有关； （3）将心脏结构和血液动力学参数的成年变化与体内脂肪，脂肪分布和无脂肪质量的同时变化以及在三年间隔内的代谢综合征相关联。我们将使用110 mg/dl的NCEP ATP III标准和美国糖尿病协会（ADA）的新推荐的100 mg/dl标准进行100 mg/dl的NCEP ATP III标准进行拟议的研究。 通过将童年数据与成人病理联系起来，阐明不良关系可能会导致检测有代谢综合征风险较高的儿童，并暗示对2型糖尿病和心血管疾病的意义。长期的长期序列记录为以经济有效的方式实现我们的目标提供了独特的机会。 FELS纵向研究的参与者在出生时就会招收，并且与任何临床状况相关的因素没有选择。因此，揭示的关系以及提出的研究提出的推论应反映肥胖，高血压，血脂异常和葡萄糖耐受性受损的自然历史，因此，应提高对代谢综合征风险的儿童的早期鉴定。