IMMUNOTHERAPY FOR PATIENTS WITH PEANUT ANAPHYLAXIS

花生过敏患者的免疫治疗

• 批准号: 6532611
• 负责人: A. Wesley Burks
• 金额: $ 13.68万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6532611
• 关键词: T cell receptor; T lymphocyte; allergens; antiallergic agents; biological signal transduction; clinical research; cytokine; food hypersensitivity; gene expression; human subject; immunoglobulin E; immunotherapy; leukocyte activation /transformation; peanuts; polymerase chain reaction; receptor binding; technology /technique development; tissue /cell culture

The applicant is a Professor in the Department of Pediatrics at the University of Arkansas for Medical Sciences. This grant application addresses the qualifications of the applicant, the mentoring plan, and the patient-oriented research plan as detailed below. This grant will be utilized t provide additional protected time to be used mentoring other individuals who are pursuing patient-oriented research and working with our Departmental Clinician Scientist mentoring program. Food allergy, an IgE- mediated disease, is a significant health problem affecting 6-8% of children and 1% of adults. Peanut hypersensitivity is one of the most common and severe of the food allergies, and the only therapeutic option currently available is food avoidance. Peanuts and peanut products are used in many different processed foods, increasing the possibility of an inadvertent ingestion. Like any other allergic disease, the events that initiate and promote peanut hypersensitivity in a susceptible individual center around the response of T cells to peanut allergens The T-cell response is mediated through the T-cell receptor (TCR) which communicates with the nucleus via a complicated array of signaling pathways. It is believed that when the TCR is occupied by an allergen in susceptible individuals the signaling pathways lead to the activation of cytokine genes that promote the synthesis of IgE. Our hypothesis for this proposal is that the cascade of events that leads to T- cell activation and promotion of IgE production can be disrupted by modifying the allergen-receptor interaction. While conventional immunotherapeutic approaches have been successful for other types of allergic diseases, these approaches have not been safe or efficacious alternatives for the treatment of peanut hypersensitivity. Some problems with standard peptide immunotherapy in the treatment of peanut hypersensitivity include severe problems with standard peptide immunotherapy in the treatment of peanut hypersensitivity include severe anaphylactic reactions, lack of detailed information about the allergens, and insufficient information about the T-cell response to peanut allergens. We propose to utilize our extensive knowledge of the allergens involved in peanut hypersensitivity to design an immunotherapeutic approach that would lower the risk of anaphylactic reactions in patients with life threatening allergic reactions to peanuts.

申请人是阿肯色医学大学儿科教授。该拨款申请涉及申请人的资格、指导计划和以患者为导向的研究计划，详情如下。这笔赠款将用于提供额外的受保护时间，用于指导其他正在进行以患者为导向的研究并与我们的部门临床医生科学家指导计划合作的个人。食物过敏是一种 IgE 介导的疾病，是影响 6-8% 儿童和 1% 成人的严重健康问题。花生过敏是最常见和最严重的食物过敏之一，目前唯一可用的治疗选择是避免食物。花生和花生制品用于许多不同的加工食品中，增加了无意摄入的可能性。与任何其他过敏性疾病一样，在易感个体中引发和促进花生过敏的事件以 T 细胞对花生过敏原的反应为中心。T 细胞反应是通过 T 细胞受体 (TCR) 介导的，TCR 与细胞核通过一系列复杂的信号通路。据信，当易感个体中的 TCR 被过敏原占据时，信号传导途径会导致细胞因子基因的激活，从而促进 IgE 的合成。我们对此提议的假设是，通过改变过敏原-受体相互作用，可以破坏导致 T 细胞激活和促进​​ IgE 产生的级联事件。虽然传统的免疫治疗方法已成功治疗其他类型的过敏性疾病，但这些方法并不是治疗花生过敏的安全或有效的替代方法。标准肽免疫疗法在治疗花生过敏中的一些问题包括标准肽免疫疗法在治疗花生过敏中的严重问题包括严重的过敏反应、缺乏关于过敏原的详细信息以及关于T细胞对花生过敏原的反应的信息不足。我们建议利用我们对花生过敏相关过敏原的广泛知识来设计一种免疫治疗方法，以降低对花生过敏反应危及生命的患者发生过敏反应的风险。