NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY

预防和治疗食物过敏的新视野

• 批准号: 10631369
• 负责人: A. Wesley Burks
• 金额: $ 299.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631369
• 关键词: 3 year old; Affect; Allergic Disease; Atopic Dermatitis; Birth; Child; Child Health; Chronic Disease; Development; Disease; Eczema; Enrollment; Family; Food; Food Hypersensitivity; Goals; Incidence; Infant; Inflammation; Life; Mothers; Phenotype; Prevention; Prevention strategy; Quality of life; Recurrence; Risk Factors; Sampling; Wheezing; cohort; cost; high risk; prenatal; primary outcome; secondary outcome; skin barrier

Project Summary: Food allergy affects approximately 5-10% of young children, with highest incidence in the first year of life. Food allergy accounts for almost $25 billion per year in U.S. costs. Atopic dermatitis [AD] (also known as eczema) is a major risk factor for food allergy and other allergic diseases, and also has a significant intrinsic impact on child health. AD affects approximately 13% of U.S. children, of whom approximately 1/3 have moderate to severe disease. AD is a chronic disease characterized by skin barrier disruption and inflammation, with ongoing major effects on the quality of life of children and families. Currently, there is no reliable way to identify those infants destined to develop atopic disease who would benefit from targeted prevention strategies. The goal of this study is to establish a birth cohort that collects prenatal and early life environmental and bio-samples and rigorously phenotypes young children for food allergy and AD to identify prenatal and early life markers of high risk for food allergy and AD.

项目概要： 食物过敏影响大约 5-10% 的幼儿，其中幼儿发病率最高 生命的一年。食物过敏每年给美国造成近 250 亿美元的损失。特应性皮炎 [AD]（也称为湿疹）是食物过敏和其他过敏性疾病的主要危险因素， 并且对儿童健康也有重大的内在影响。 AD 影响了大约 13% 的美国人口 儿童，其中约 1/3 患有中度至重度疾病。 AD是一种慢性疾病 以皮肤屏障破坏和炎​​症为特征，对皮肤持续产生重大影响 儿童和家庭的生活质量。目前，还没有可靠的方法来识别这些婴儿 注定会患上特应性疾病的人将从有针对性的预防策略中受益。这 这项研究的目标是建立一个出生队列，收集产前和早期生活环境 对幼儿进行生物样本和严格的表型分析以识别食物过敏和 AD 食物过敏和 AD 高风险的产前和早期生命标志。

项目成果

Urticaria and/or angioedema secondary to mRNA COVID-19 vaccines: Updates from a United States case registry.

mRNA COVID-19 疫苗继发的荨麻疹和/或血管性水肿：美国病例登记处的更新。

• 发表时间: 2023-01
• 影响因子: 12.4
• 作者: Anvari, Sara;Samarakoon, Upeka;Fu, Xiaoqing;Jaggers, Jordan;Gonzalez;Chong, Hey Jin;Van Meerbeke, Sara W;Petrov, Andrej A;Khan, David A;Freeman, Esther E;Banerji, Aleena;Blumenthal, Kimberly G
• 通讯作者: Blumenthal, Kimberly G

Anaphylaxis after COVID-19 vaccination: A registry-based study.

COVID-19 疫苗接种后的过敏反应：一项基于登记的研究。

• 发表时间: 2022-11
• 作者: Jaggers, Jordon;Samarakoon, Upeka;Fu, Xiaoqing;Gonzalez;Anvari, Sara;Chong, Hey Jin;Van Meerbeke, Sara W;Petrov, Andrej A;Chow, Timothy G;Banerji, Aleena;Judd, Allen;Blumenthal, Kimberly G
• 通讯作者: Blumenthal, Kimberly G

The Consortium for Food Allergy Research (CoFAR): The first generation.

食物过敏研究联盟 (CoFAR)：第一代。

• 发表时间: 2019
• 作者: Sampson, Hugh A;Berin, M Cecilia;Plaut, Marshall;Sicherer, Scott H;Jones, Stacie;Burks, A Wesley;Lindblad, Robert;Leung, Donald Y M;Wood, Robert A
• 通讯作者: Wood, Robert A

Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection.

鼠疫耶尔森氏菌肺部感染期间中性粒细胞初级颗粒释放的抑制。

• 发表时间: 2019
• 影响因子: 6.4
• 作者: Eichelberger, Kara R;Jones, Grant S;Goldman, William E
• 通讯作者: Goldman, William E