Genetics of Attention Deficit Hyperactivity Disorder

注意力缺陷多动障碍的遗传学

• 批准号: 6830467
• 负责人: Maximilian Muenke
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6830467
• 关键词: Hispanic Americans; attention deficit disorder; biotechnology; blood tests; brain disorders; clinical research; computer simulation; family genetics; generation difference; genetic disorder; genetic screening; genome; human subject; linkage mapping; middle childhood (6-11); psychological tests; siblings

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage. The next phase of our research on ADHD involves US families with ADHD.

注意缺陷多动症（ADHD）是一种受遗传影响的脑疾病，学龄儿童患病率为3-5％。已招募了受影响的兄弟姐妹对，并受到严重影响的多代西班牙裔家庭。链接到多动症的基因组的全基因组搜索已经完成。参与的个体接受了一系列心理测试，并为连锁分析和位置克隆研究吸收了血液，这些研究被用来寻找与ADHD相关的基因。迄今为止，我们拥有有关15个大型多代西班牙裔家庭的完整信息。对27种信息的模拟研究表明，检测连锁的功能很高。我们对多动症的研究的下一阶段涉及我们患有多动症的家庭。