Emergence:Co-occurring Depression/Externalizing Problems

出现：同时发生的抑郁/外化问题

• 批准号: 6782695
• 负责人: ANN VANDER STOEP
• 金额: $ 42.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-16 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6782695
• 关键词: angers; attribution; behavioral /social science research tag; child behavior disorders; child mental disorders; child psychology; clinical research; comorbidity; conduct disorder; conflict; depression; developmental psychology; disease /disorder onset; guilt; human subject; interview; longitudinal human study; mental disorder diagnosis; middle childhood (6-11); mood disorders; outcomes research; perception disorder; psychopathology; questionnaires; self concept; social psychology; social support network; violence

DESCRIPTION (provided by applicant): This application entitled: "Emergence of Co-occurring Depressive and Externalizing Problems: Phenomenology, Course, and Outcome" was written as a response to RFA: MH-01-002. The Principal Investigator is a new investigator, who has convened a team of experienced developmental psychologists and research methodologists. Mental illness is a significant public health problem that is common in children and adversely affects their development. According to the recently published Surgeon General's Report, "mental illnesses exact a staggering toll on millions of individuals, as well as on their families and communities, and our Nation as a whole." Critical to the Healthy People 2010 objective of reducing the prevalence of mental disorders among children and adolescents is a clearer understanding of the developmental processes underlying childhood psychopathology. For children who have mental disorders, co-occurrence of multiple disorders is more the rule than the exception. Yet very little is known about the differences in phenomenology, course, and outcome when disorders co-occur and when they do not. The proposed study is designed to identify developmental precursors, describe phenomenology, document developmental sequences, identify moderators and mediators of longitudinal course, and document functional outcomes in four groups of children. Study subjects will include children in three "vulnerable" groups: depressive, only; externalizing, only; and co-occurring depressive and externalizing; and a comparison group of children without these vulnerabilities. The study will be conducted in King County, Washington. Study subjects will be selected on the basis of school problem status and parent-reported internalizing and externalizing problems from among 6th grade students in the Seattle Public Schools. In-person structured interviews focusing on key study constructs will be conducted with children and their caregivers and teachers at Baseline and at 12 and 24-month follow-up, with telephone/mail interviews conducted at intervening points. To address study aims, longitudinal data will be analyzed using logistic regression, Cox proportional hazards, growth mixture models, and classification and regression tree (CART) methods. Understanding the nature of co-occurring psychopathology will have important implications for nosology, as well as for the development of effective prevention and treatment approaches. The availability of a diverse population of children, the collaborative relationship between the University of Washington and the Seattle Public School District, and the experienced team of researchers create excellent conditions to conduct a study that can specifically address the questions posed in this RFA.

描述（申请人提供）：此申请标题为： 共同出现的抑郁和外部化问题：现象学，课程和 结果”是作为对RFA的回应：MH-01-002。校长 调查员是一名新调查员，他召集了一支经验丰富的团队 发展心理学家和研究方法学家。 精神疾病是一个重大的公共卫生问题，很常见 儿童和不利影响他们的发展。根据最近 发表的外科医生的报告“精神疾病肯定是惊人的损失 关于数百万个人以及他们的家庭和社区，以及 我们的整个国家。 减少儿童和青少年精神障碍的患病率是 对童年的发展过程的更清晰了解 心理病理学。对于患有精神障碍的儿童 多种疾病比例外更多。但是很少 知道现象学，过程和结果的差异 疾病同时发生，当它们没有。 拟议的研究旨在识别发育前体，描述 现象学，文档发育序列，识别主持人和 纵向课程的调解人，并记录四个功能结果 一群孩子。研究科目将包括三个“脆弱”的孩子 小组：抑郁症，仅；仅外在化；和同时发生的抑郁症和 外部化；还有一个没有这些的儿童的比较组 漏洞。 该研究将在华盛顿的金县进行。研究科目将是 根据学校问题状况和父母报告选择 在六年级学生中的内部化和外部化问题 西雅图公立学校。面对面的面对关键研究的结构化访谈 构造将与儿童及其照顾者和老师一起进行 基线以及12个月和24个月的随访，电话/邮件采访 在干预点进行。为了解决研究目标，纵向数据将 使用逻辑回归，COX比例危害，生长混合物进行分析 模型，分类和回归树（CART）方法。 了解同时发生的心理病理学的性质将具有重要的 对疾病的影响以及有效的发展 预防和治疗方法。多样化人口的可用性 儿童，大学之间的协作关系 华盛顿和西雅图公立学区，以及经验丰富的团队 研究人员创造了良好的条件，以进行研究 专门解决此RFA中提出的问题。