Hemodynamic predictors of brain and cognitive aging

大脑和认知衰老的血流动力学预测因子

• 批准号: 6829234
• 负责人: NAFTALI RAZ
• 金额: $ 5.86万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829234
• 关键词: aging; atrophy; blood pressure; brain morphology; cerebral artery; clinical research; cognition; hemodynamics; human subject; longitudinal human study; magnetic resonance imaging; neuropsychological tests; prefrontal lobe /cortex; questionnaires; short term memory; ultrasound blood flow measurement; ultrasound echoencephalography; white matter

DESCRIPTION (provided by applicant): This research project is proposed in response to the small grants program announcement of the National Institute on Aging (PAR-03-056). Specifically, we respond to the aims #2 (Cardiovascular and Cerebrovascular Aging), and #16 (Executive Function) on the list of objectives in that announcement. The main goal of the proposed research is to explore the feasibility of using Transcranial Doppler Sonography (TCD) for assessment of the influence exerted by hemodynamic factors on differential age related changes in brain and cognition. We are specifically interested in exploring the links between age-related slowing of cerebral arterial blood velocity (CBF-V) in anterior and middle cerebral arteries, as a marker for cerebral hypoperfusion, and regional increase in white matter hyperintensities (WMH) burden as well as shrinkage of the cortex and the underlying white matter. In cognitive domain we will focus in the executive functions which are differentially sensitive to aging and prefrontal pathology. Our hypotheses are based on the body of clinical and preclinical studies that suggested CBF-V slowing as risk factor for developing WMH, our own studies that support the plausibility of modifying influence of cerebrovascular risk factors on age-related brain shrinkage and on the studies that suggest differential vulnerability of executive functions to mild hypertension. While a preliminary report [5] indicates that reduced CBF-V may be associated with structural brain pathology (global WMH burden), neither regional specificity, nor cognitive relationship nor longitudinal course of that index have been established. We have conducted research on a cohort of healthy adults (age 18-85) and obtained cognitive and MRI-based structural brain measures on more than 100 individuals. In this project, we propose to use these data as baseline measures in a two-year longitudinal study and to relate hemodynamic variables to the rate of neuroanatomical and cognitive change. Thus, the proposed research fits the announced goals of the program in that it represents a pilot study that will examine feasibility of application of a technique widely used in the clinic to research on healthy aging, and it will benefit from statistical analysis of existing data.

描述（由申请人提供）：该研究项目是针对美国国家老化研究所的小额赠款计划（PAR-03-056）提出的。具体来说，我们在该公告中的目标列表中回应了目标＃2（心血管和脑血管老化）和＃16（执行功能）。拟议研究的主要目的是探索使用经颅多普勒超声检查（TCD）评估血液动力学因素对脑和认知差异相关变化所施加的影响的可行性。我们特别有兴趣探索脑动脉血速速度（CBF-V）在前和中大脑中动脉中的联系，作为大脑灌注不足的标志，是白质量超强度（WMH）负担的区域性增加，以及cortexex的buninkex and shrinkex and shrinkex niffere and the Corninkex niffere。在认知领域，我们将重点关注对衰老和额叶病理学差异敏感的执行功能。我们的假设是基于临床和临床前研究的体系，该研究表明CBF-V减缓是开发WMH的危险因素，我们自己的研究支持了修改脑血管风险因素对年龄相关的脑收缩的影响的合理性，以及对高度高压率轻度高度高压率的执行功能不同的研究的研究。虽然初步报告[5]表明，减少的CBF-V可能与结构性脑病理学（全球WMH负担）有关，但该指数的区域特异性，认知关系或纵向过程均未建立。我们已经对健康成年人（18-85岁）的队列进行了研究，并获得了100多名个人的认知和基于MRI的结构性脑测量。在该项目中，我们建议在两年的纵向研究中使用这些数据作为基线度量，并将血液动力学变量与神经解剖学和认知变化的速度相关联。因此，拟议的研究符合该计划的宣布的目标，因为它代表了一项试点研究，该研究将研究应用于诊所中广泛用于研究健康衰老的技术的可行性，并且它将受益于现有数据的统计分析。