Hemodynamic predictors of brain and cognitive aging

大脑和认知衰老的血流动力学预测因子

• 批准号: 6829234
• 负责人: NAFTALI RAZ
• 金额: $ 5.86万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829234
• 关键词: aging; atrophy; blood pressure; brain morphology; cerebral artery; clinical research; cognition; hemodynamics; human subject; longitudinal human study; magnetic resonance imaging; neuropsychological tests; prefrontal lobe /cortex; questionnaires; short term memory; ultrasound blood flow measurement; ultrasound echoencephalography; white matter

DESCRIPTION (provided by applicant): This research project is proposed in response to the small grants program announcement of the National Institute on Aging (PAR-03-056). Specifically, we respond to the aims #2 (Cardiovascular and Cerebrovascular Aging), and #16 (Executive Function) on the list of objectives in that announcement. The main goal of the proposed research is to explore the feasibility of using Transcranial Doppler Sonography (TCD) for assessment of the influence exerted by hemodynamic factors on differential age related changes in brain and cognition. We are specifically interested in exploring the links between age-related slowing of cerebral arterial blood velocity (CBF-V) in anterior and middle cerebral arteries, as a marker for cerebral hypoperfusion, and regional increase in white matter hyperintensities (WMH) burden as well as shrinkage of the cortex and the underlying white matter. In cognitive domain we will focus in the executive functions which are differentially sensitive to aging and prefrontal pathology. Our hypotheses are based on the body of clinical and preclinical studies that suggested CBF-V slowing as risk factor for developing WMH, our own studies that support the plausibility of modifying influence of cerebrovascular risk factors on age-related brain shrinkage and on the studies that suggest differential vulnerability of executive functions to mild hypertension. While a preliminary report [5] indicates that reduced CBF-V may be associated with structural brain pathology (global WMH burden), neither regional specificity, nor cognitive relationship nor longitudinal course of that index have been established. We have conducted research on a cohort of healthy adults (age 18-85) and obtained cognitive and MRI-based structural brain measures on more than 100 individuals. In this project, we propose to use these data as baseline measures in a two-year longitudinal study and to relate hemodynamic variables to the rate of neuroanatomical and cognitive change. Thus, the proposed research fits the announced goals of the program in that it represents a pilot study that will examine feasibility of application of a technique widely used in the clinic to research on healthy aging, and it will benefit from statistical analysis of existing data.

描述（由申请人提供）：本研究项目是为了响应国家老龄化研究所小额赠款计划公告（PAR-03-056）而提出的。具体来说，我们对该公告中的目标清单中的目标#2（心血管和脑血管衰老）和目标#16（执行功能）做出了回应。本研究的主要目标是探索使用经颅多普勒超声检查（TCD）评估血流动力学因素对大脑和认知的不同年龄相关变化的影响的可行性。我们特别感兴趣的是探索大脑前动脉和中动脉中与年龄相关的脑动脉血流速度（CBF-V）减慢（作为脑灌注不足的标志）与白质高信号（WMH）负担的区域增加之间的联系作为皮质和下面的白质的收缩。在认知领域，我们将重点关注对衰老和前额叶病理有不同敏感性的执行功能。我们的假设基于大量临床和临床前研究，这些研究表明 CBF-V 减慢是发生 WMH 的危险因素，我们自己的研究支持改变脑血管危险因素对与年龄相关的大脑萎缩的影响的合理性，以及基于以下研究：表明执行功能对轻度高血压的不同脆弱性。虽然初步报告 [5] 表明 CBF-V 减少可能与结构性脑病理学（全球 WMH 负担）有关，但该指数的区域特异性、认知关系或纵向过程均尚未确定。我们对一组健康成年人（18-85 岁）进行了研究，并获得了 100 多人的认知和基于 MRI 的大脑结构测量结果。在这个项目中，我们建议使用这些数据作为为期两年的纵向研究的基线测量，并将血流动力学变量与神经解剖学和认知变化率联系起来。因此，拟议的研究符合该计划已宣布的目标，因为它代表了一项试点研究，将检验临床广泛使用的技术应用于健康老龄化研究的可行性，并将受益于现有数据的统计分析。