Core--Pharmacology Facility

核心--药理设施

基本信息

批准号：
6998199
负责人：
HOWARD L MCLEOD
金额：
$ 10.32万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-21 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6998199
关键词：
antineoplastics biomedical facility drug metabolism experimental designs high performance liquid chromatography method development neoplasm /cancer neoplasm /cancer pharmacology training

项目摘要

The Pharmacology Core provides analytical support for basic and clinical scientists at the Siteman Cancer Center (SCC) that would not otherwise be available. This has ranged from plasma analysis and/or pharmacokinetic modeling of arsenic trioxide, all trans retinoic acid, celecoxib, doxil, irinotecan, hydroxychloroquine, topotecan, UCN-01, cisplatin, docetaxel, paclitaxel, and PSC833 to support of preclinical and clinical studies. The core also provides the only source of support for SCC members to design and analyze novel studies of drug disposition. The core provides preclinical metabolism and elimination studies, and it plays a role in the cancer pharmacology education and training of SCC members and Barnes Jewish Hospital/Washington University clinical trainees. The Pharmacology Core offers the following services: . Pharmacology trial design and analyses . Analytical assay development and validation (HPLC) . Preclinical metabolism and elimination studies (in vitro, ex vivo, in vivo) . Pharmacokinetic/Pharmacodynamic studies . Education and training . Regional pharmacology resource for other academic institutions

药理学核心为现场癌症中心（SCC）的基本和临床科学家提供了分析支持，否则就无法获得。 This has ranged from plasma analysis and/or pharmacokinetic modeling of arsenic trioxide, all trans retinoic acid, celecoxib, doxil, irinotecan, hydroxychloroquine, topotecan, UCN-01, cisplatin, docetaxel, paclitaxel, and PSC833 to support of preclinical and clinical studies.核心还为SCC成员提供了设计和分析新颖的药物处置研究的唯一支持来源。核心提供了临床前的代谢和消除研究，它在SCC成员的癌症药理学教育和培训中发挥了作用，巴恩斯犹太医院/华盛顿大学临床学员。药理学核心提供以下服务：。药理学试验设计和分析。分析测定开发和验证（HPLC）。临床前代谢和消除研究（体内，体内，体内）。药代动力学/药效学研究。教育和培训。其他学术机构的区域药理学资源