CORE--PHARMACOLOGY

核心--药理学

• 批准号: 6651722
• 负责人: JOHN KUHN
• 金额: $ 25.41万
• 依托单位: CTRC RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-26 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651722
• 关键词: analytical chemistry; antineoplastics; atomic absorption spectrometry; biomedical facility; capillary electrophoresis; clearance rate; computer data analysis; computer program /software; drug metabolism; drug screening /evaluation; experimental designs; high performance liquid chromatography; liquid chromatography mass spectrometry; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; pharmacokinetics; training

DESCRIPTION (provided by applicant): The mission of the Pharmacology Shared Resource is to provide a stable, centralized resource to the members of the San Antonio Cancer Institute for the design, implementation and evaluation of preclinical or clinical pharmacology studies of anticancer or biological agents in a reliable timely and cost-efficient manner. The services provided by the Pharmacology Shared Resource include: Design of Clinical and Laboratory Studies; Assistance is provided to investigators in protocol design and grant submission of preclinical and clinical pharmacology studies taking into account the requirements for numbers of patients or animals, sampling schedules, limitations of sample volume, sample processing and storage, analytical analysis and budgetary considerations; Specimen Analysis. A wide range of analytical support is provided by developing or implementing suitable analytical or biological methodologies under good laboratory science guidelines for the measurement of drugs or surrogate makers in biological fluids and/or tissue; Pharmacokinetic/Pharmacodynamic Analyses. Pharmacokinetic and pharmacodynamic analyses are performed using both commercially available software and customized pharmacokinetic programs, followed by a report and interpretation of the data; Education. Core personnel provide education and training to students, postdoctoral fellows and SACI investigators through presentations or informal meetings on the performance of preclinical/clinical pharmacology studies. The Pharmacology Shared Resource consists of three 600 square foot analytical laboratories and one 600 square foot molecular pharmacotherapy laboratory, located on the third floor of the UTHSCSA Robert F. McDermott Clinical Sciences Building. Specialized technology provided by the core include analysis of oligonucleotides or gene quantification by capillary electrophoresis and measurement of compounds by LC/MS not quantified by standard analytical methods.

描述（由申请人提供）：药理学的任务共享 资源是为成员提供稳定的集中资源 圣安东尼奥癌症设计，实施和评估研究所 抗癌或生物学的临床前或临床药理学研究 代理商以可靠的及时和成本效益的方式。提供的服务 由药理学共享资源包括：临床设计和 实验室研究；协议向调查人员提供协助 临床前和临床药理学研究的设计和授予提交 考虑到患者或动物数量的要求， 采样时间表，样本量的限制，样品处理和 存储，分析分析和预算考虑因素；标本分析。 通过开发或实施提供广泛的分析支持 良好的实验室科学下的合适分析或生物学方法论 测量药物或替代制造商的指南 液体和/或组织；药代动力学/药效分析。 使用两者都进行药代动力学和药效学分析 市售软件和定制的药代动力学程序， 然后是数据的报告和解释；教育。核 人员为学生，博士后研究员和 SACI调查人员通过演讲或非正式会议 临床前/临床药理学研究的性能。药理学 共享资源由三个600平方英尺的分析实验室和 一个600平方英尺的分子药物治疗实验室，位于第三个 Uthscsa Robert F. McDermott临床科学大楼的地板。 核心提供的专业技术包括分析 毛细管电泳和基因定量寡核苷酸或基因定量 通过标准分析量化LC/MS对化合物的测量 方法。