Mind-Body Interactions in Cardiosvascular Disease

心血管疾病中的身心相互作用

• 批准号: 6814770
• 负责人: Viola Vaccarino
• 金额: $ 10.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6814770
• 关键词: behavioral /social science research tag; biomarker; blood chemistry; cardiovascular disorder; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular function; clinical research; depression; electrocardiography; environmental stressor; family genetics; gene environment interaction; genetic susceptibility; hormone regulation /control mechanism; human subject; hypothalamic pituitary adrenal axis; molecular pathology; neuropsychological tests; neuropsychology; neuroregulation; oxidative stress; patient oriented research; positron emission tomography; twin /multiplet

DESCRIPTION (provided by applicant): This is an application for a Mid-Career Investigator Award in Patient-Oriented Research (K24) for Viola Vaccarino, MD, PhD. The overall objective is to foster Dr. Vaccarino's academic career and that of new investigators working with her in patient-oriented research involving mind-body relationships in cardiovascular disease. The PI seeks protected time to continue ongoing projects, carry out novel research projects, and mentor junior investigators in this area. The PI has had a long-standing interest in the relationship between psychological/behavioral factors, in particular depression, and the incidence or prognosis of CVD. Recently her research focus has shifted towards a more direct investigation of the pathophysiological mechanisms that mediate these associations in the early phases of coronary heart disease in humans, including the autonomic nervous system, neuro-hormonal factors, inflammation, oxidative stress, and gene-environment interactions. The PI has a growing program in this area. However, she needs protected time to expand her research by obtaining new research grants in this area. An important goal of Dr. Vaccarino's career development is to enhance her mentorship activities and ultimately establish a strong training program to foster the next generation of patient-oriented researchers in this area. Dr. Vaccarino has already been quite successful in attracting new investigators to this area of research and in guiding them towards obtaining independent funding. A number of training programs available at Emory represent a source of capable junior investigators. Dr. Vaccarino seeks protected time to continue her mentorship activities and expand them to attract a larger number of beginning investigators. She also plans to apply for a T32 training grant to develop a formal educational program in clinical/epidemiological research as it applies to cardiovascular diseases. Such a program is currently non-existent at Emory. Dr. Vaccarino's long-term goal is to establish a strong research and training patient-oriented research program at Emory focusing on mind-body interactions on cardiovascular disease. Such a program will draw collaborators from multiple departments and disciplines, will foster the training and career development of new investigators, will draw the recruitment of new faculty with interest in this area and will ultimately contribute enormously to the advancement of this field.

描述（由申请人提供）： 这是申请中Viola Vaccarino，MD，PhD的患者研究研究员奖（K24）。总体目的是培养Vaccarino博士的学术生涯，以及与她从事心脏血管疾病中心身关系的新研究人员的研究。 PI寻求受保护的时间继续进行持续的项目，进行新的研究项目，并在该领域指导初级研究人员。 PI对心理/行为因素（尤其是抑郁症）与CVD的发生率或预后之间的关系长期存在兴趣。最近，她的研究重点转向了对人类冠心病早期阶段中这些关联的病理生理机制的更直接研究，包括自主神经系统，神经激素因素，炎症，氧化应激，氧化应激和基因环境相互作用。 PI在该领域有一个不断增长的计划。但是，她需要受到保护的时间来扩大她的研究，通过在该领域获得新的研究补助金。 Vaccarino博士职业发展的一个重要目标是增强她的指导活动，并最终建立强大的培训计划，以培养该领域的下一代以患者为导向的研究人员。 Vaccarino博士已经在吸引新的研究人员进入这一研究领域并指导他们获得独立资金方面已经取得了很大成功。 Emory提供的许多培训计划代表了有能力的初级调查人员的来源。 Vaccarino博士寻求受保护的时间继续她的指导活动并扩大它们，以吸引更多的初学者调查人员。她还计划申请T32培训补助金，以制定适用于心血管疾病的临床/流行病学研究的正式教育计划。这种程序目前在Emory中不存在。 Vaccarino博士的长期目标是在埃默里（Emory）建立强大的研究和培训以患者为导向的研究计划，重点介绍有关心血管疾病的心身相互作用。这样的计划将吸引来自多个部门和学科的合作者，促进新调查人员的培训和职业发展，将吸引对该领域感兴趣的新教师的招聘，并最终为该领域的发展做出巨大贡献。