Correlating drug effects on the VOR and motion sickness

药物对 VOR 和晕动病的影响相关

• 批准号: 6799239
• 负责人: PHILLIP D KRAMER
• 金额: $ 7万
• 依托单位: JFK MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6799239
• 关键词: adult human (21+); clinical research; diazepam; drug screening /evaluation; histamine; human subject; inhibitor /antagonist; motion perception; outcomes research; patient oriented research; pharmacokinetics; proprioception /kinesthesia; vestibuloocular reflex

DESCRIPTION (provided by applicant): Correlate diazeparn and meclizine's effects on the vestibular ocular reflex (VOR) with their ability to suppress motion sickness. Study design and methodology: Thirty subjects will have their vestibular (VOR gain, time constant, and reversal phase) and oculomotor function (gaze holding in the dark, OKN, and OKAN) tested at baseline and again two hours later. Immediately following the first set of tests the subject will ingest placebo, diazepam, meclizine, or nothing (randomized double blind order). After the second set of tests subjects will be exposed to a stimulus that promotes motion sickness. The subjects will make head movements while rotating at 120 deg/sec until they have reached a predetermined level of motion sickness defined by the Massachusetts Institute of Technology's modification of the Pensacola Diagnostic Index as Malaise III and note the number of head movements made until that point. Data will be examined for the correlation between the magnitude of the changes (with and without medication) of the VOR measurements and the difference in motion sickness susceptibility. The coefficients of a linear control system model of the vestibular and oculomotor systems will be manipulated to simulate the test results. The changes to the model may reflect functional localization of drug effects on the VOR, which may imply anatomical localization. Objectives: The vestibular system is a central component of both motion sickness and vestibular dizziness (vertigo) and both are treated with many of same medications including diazeparn and meclizine. Little is known, however, about their mechanisms of action in either motion sickness or vertigo. The objective of this study is to determine if diazeparn and meclizine's ability to prevent motion sickness is related to their ability to affect the VOR. This information is intended to help health care providers better treat patients with vertigo.

描述（由申请人提供）：将地西eparn和麦克洛宁对前庭眼反射（VOR）的影响与抑制运动疾病的能力相关联。 研究设计和方法论：三十个受试者将在基线和两个小时后再次测试其前庭（VOR增益，时间常数和逆转阶段）和眼动函数（凝视在黑暗，OKN和OKAN）。在第一组测试之后，受试者将立即摄取安慰剂，地西ep剂，麦克洛嗪或Nothing（随机双盲秩序）。在第二组测试之后，受试者将暴露于促进运动疾病的刺激中。受试者将在120度/秒旋转时进行头部移动，直到他们达到了马萨诸塞州技术研究所所定义的预定水平的运动疾病水平，该研究所的彭萨科拉诊断指数将其变量为不适III，并注意到直到那一点的头部运动次数。 将检查数据是否在VOR测量的变化（有或不使用药物）的大小与运动敏感性差异之间的相关性。将操纵前庭和动眼系统的线性控制系统模型的系数以模拟测试结果。该模型的变化可能反映了药物对VOR的作用的功能定位，这可能意味着解剖学定位。 目的：前庭系统是运动疾病和前庭头晕（Vertigo）的核心组成部分，并且两者都经过许多相同的药物治疗，包括地西eparn和Meclizine。然而，关于它们在运动疾病或眩晕中的作用机制知之甚少。这项研究的目的是确定地西eparn和Meclizine预防运动疾病的能力是否与影响VOR的能力有关。该信息旨在帮助医疗保健提供者更好地治疗眩晕患者。