The Barbados Study of Ocular Conditions (BSOC)

巴巴多斯眼部疾病研究 (BSOC)

• 批准号: 6777418
• 负责人: SUH-YUH Y WU
• 金额: $ 18.98万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777418
• 关键词: African Caribbean; cataract; clinical research; disease /disorder proneness /risk; epidemiology; eye refraction disorder; glaucoma; human data; human mortality; intraocular pressure; longitudinal human study; myopia; quality of life; vision

DESCRIPTION (provided by applicant): The proposed study would utilize the comprehensive dataset of the Barbados Eye Studies (BESs), which were based on a black population, to address some unanswered questions that are of clinical and public health importance. The specific aims of this proposal do not include the major goals of the BESs, which are addressed elsewhere. Instead, the proposed project would analyze the BESs data to evaluate: 1) The 9- year natural history of intraocular pressure (lOP) and the relationship between changes in lOP and possible risk factors; 2) The 9-year natural history of myopia and hyperopia and associations between changes in these conditions and potential risk factors; 3) The 9-year risk of mortality in persons with cataract and glaucoma; and 4) Visual functioning-related quality of life. The BESs are a series of large epidemiologic studies aimed at investigating the major causes of visual loss in a predominantly black population, providing extensive data on prevalence, incidence and risk factors for major eye diseases. They include the Barbados Eye Study (BES), 1987-1992, and the Barbados Incidence Study of Eye Diseases I and II (BISED I and II), 1992-2003. The study examinations were standardized and extensive, including refraction, visual acuity, Humphrey perimetry, applanation tonometry, lens gradings, blood pressure and anthropometric measurements, medical history and other interview data, glycosylated hemoglobin, and stereo fundus photographs of the disc and macula. The BISED II protocol was extended to include pachymetry measurements and a vision-related quality of life component. Throughout all study phases, mortality data were monitored and relevant information from death certificates was abstracted. The dataset is a unique resource to learn more about ophthalmic diseases in persons of African descent and address questions about their natural history. The considerably high participation in the cohort (84% in BES, 85% in BISED, and 81% in BISED II), as well as the experience of the research team support the feasibility and yield of the proposed study.

描述（由申请人提供）：拟议的研究将利用基于黑人人群的巴巴多斯眼睛研究（BESS）的综合数据集来解决一些临床和公共健康重要性的未解决问题。 该提案的具体目的不包括在其他地方解决的贝丝的主要目标。 取而代之的是，拟议的项目将分析BESS数据以评估：1）9年年的自然历史（LOP）以及LOP变化与可能的风险因素之间的关系； 2）近视和远视的9年自然历史以及这些条件变化与潜在危险因素之间的关联； 3）白内障和青光眼患者死亡的9年风险； 4）与视觉功能相关的生活质量。 BESS是一系列大型流行病学研究，旨在研究主要黑人人群中视觉丧失的主要原因，从而提供有关主要眼病的患病率，发病率和危险因素的广泛数据。 它们包括Barbados眼研究（BES），1987- 1992年，以及II和II的Barbados发病率研究（BISED I和II），1992- 2003年。 研究检查是标准化和广泛的，包括折射，视敏度，汉弗莱阴，施加量计，镜头分级，血压和人体测量测量，病史和其他访谈数据，糖基化的血红蛋白以及立体声供应二张和毛糖的立体遗产照片。 扩展了BISED II方案，包括式式测量和与视觉相关的生活质量组成部分。 在所有研究阶段中，都监测了死亡率数据，并抽象了来自死亡证书的相关信息。 该数据集是一种独特的资源，可以在非洲血统中更多地了解有关眼科疾病的更多信息，并解决有关其自然历史的问题。 参与该队列的高度参与（BES 84％， 85％的BISED，在BISED II）中获得81％，研究小组的经验支持拟议研究的可行性和产量。