Univ.of Calif., Irvine Cancer Center Support Grant

加州大学欧文癌症中心支持补助金

• 批准号: 6660682
• 负责人: FRANK L. MEYSKENS
• 金额: $ 261.74万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660682
• 关键词: biomedical facility; neoplasm /cancer

The University of California, Irvine Comprehensive Cancer Center is a matrix-type organization. The research goals of the Cancer Center are: 1) To contribute to understanding of the basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials. Whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multi-cultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary research. The Cancer Center serves over 5 million people in Orange, Riverside, and San Bernardino Counties. Cancer Center members entered over 2000 participants or patients on prevention and treatment protocols in the year 2000. An extensive community research clinical trials network for gynecologic malignancies has been established in the Southern California region and beyond. A Clinical Trials Protocol Review and Monitoring System is functioning well. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control Research and Education and Training. The Divisions interact through eight research programs: Carcinogenesis, Growth Factors and Signaling, Developmental Biology, Virology, Translational Oncology, Photomedicine, and Population Sciences. The Center provides centralized support for these program functions through seven shared resource facilities: Biostatistics, Clinical Research Office, DNA Sequencing, Biomedical Protein and Mass Spectrometry, Optical Biology, Transgenic Mouse, and Viral Vectors. Three new shared resources are also proposed: Onco-Imaging, Microarray, and Translational Pathology. The Education and Training Division facilitates integration of students into basic, clinical, and control research activities in the various programs and accordingly enhances the translational capabilities of the Center. Developmental funds are used to recruit faculty in areas of research the Center has identified has high priority to provide seed grants that will support collaborative translational cancer research of Center members.

加利福尼亚大学尔湾综合癌症中心是矩阵类型的组织。癌症中心的研究目标是：1）有助于理解癌症表型和基因型的基本机制； 2）促进将实验室和流行病学研究转化为假设驱动的临床预防和治疗研究； 3）进行临床预防试验。只要可能从中心产生的研究中发出； 4）定义该中心服务的各种社会经济和多元文化社会中的癌症风险，并制定研究策略，以促进这些人群中癌症的预防和早期发现； 5）利用各个级别的广泛的教育和培训机会作为主要的转化工具，并鼓励促进跨学科研究的活动。 癌症中心在奥兰治，河滨和圣贝纳迪诺县为超过500万人提供服务。癌症中心成员在2000年进入了2000多名参与者或患者进行预防和治疗方案。在南加州地区及其他地区建立了广泛的社区研究临床试验网络。临床试验协议审查和监测系统运行良好。 该中心分为四个主要部门：基础科学，临床研究，癌症控制研究以及教育和培训。这些分裂通过八个研究计划相互作用：癌变，生长因子和信号传导，发育生物学，病毒学，转化肿瘤学，摄影医学和人口科学。该中心通过七个共享资源设施为这些程序功能提供集中支持：生物统计学，临床研究办公室，DNA测序，生物医学蛋白和质谱，光学生物学，转基因小鼠和病毒载体。还提出了三个新的共享资源：onco成像，微阵列和翻译病理学。教育和培训部有助于将学生整合到各种计划中的基础，临床和控制研究活动中，并因此增强了中心的转化能力。发展基金用于在该中心确定的研究领域招募教职员工，因此优先级优先提供种子赠款，以支持中心成员的协作转化癌症研究。