CORE--BIOENGINEERING

核心--生物工程

• 批准号: 6663053
• 负责人: ALFRED L NUTTALL
• 金额: $ 19.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6663053
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biomedical facility; brain stem; cochlea; cochlear microphonic potentials; computer program /software; computer system design /evaluation; electrophysiology; gerbil /jird; guinea pigs; hearing; information systems; laboratory mouse; otoacoustic emission

The Oregon Hearing Core (OHCC) Bioengineering Core (Core 1) will support six of the OHCC users and four collaborating investigators. The purpose of the Bioengineering core is to provide engineering and software expertise and to provide electrophysiological characterization of certain animals needed in projects of the users. In engineer will design and build custom electronic and mechanical devices that solve experimental and data acquisition problems. A computer programmer will write computer software (e.g. a Lab View virtual instrument) to address the experimental needs of the users. Projects undertaken by engineer and programmer will extend the funded work of the core users and stimulate collaborative studies between users. The programmer will help create common data bases that would allow sharing of experimental data among users. In addition, an electrophysiology technician will be available to measure (in mice, guinea pigs or gerbils) auditory brainstem responses, cochlear compound action potentials, distortion product otoacoustic emissions, and endocochlear potentials. An important activity of the technician will be to characterize the functional status of the cochlea in mutant mice produced by the OHCC Mouse Molecular Genetics Core. As for the engineer and programmer, the technician will work with Core users to extend work on supported R01s and enhance collaborative studies.

俄勒冈州听力核心 (OHCC) 生物工程核心（核心 1）将支持六名 OHCC 用户和四名合作研究人员。生物工程核心的目的是提供工程和软件专业知识，并提供用户项目中所需的某些动物的电生理学特征。 工程师将设计和构建定制电子和机械设备，以解决实验和数据采集问题。计算机程序员将编写计算机软件（例如 Lab View 虚拟仪器）来满足用户的实验需求。工程师及承担的项目 程序员将扩展核心用户的资助工作并激发用户之间的协作研究。程序员将帮助创建通用数据库，允许用户之间共享实验数据。 此外，电生理学技术人员将可以测量（小鼠、豚鼠或沙鼠）听觉脑干反应、耳蜗复合动作电位、畸变产物耳声发射和耳蜗内电位。技术人员的一项重要活动是表征 OHCC 小鼠分子遗传学核心产生的突变小鼠的耳蜗功能状态。至于工程师和程序员，技术人员将与 Core 用户合作，扩展受支持的 R01 的工作并加强协作研究。