Exhaled Air Biomarkers in COPD

慢性阻塞性肺病 (COPD) 中的呼出空气生物标志物

• 批准号: 6780965
• 负责人: NORBERT F VOELKEL
• 金额: $ 31.7万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-26 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780965
• 关键词: adult human (21+); apoptosis; biomarker; chronic obstructive pulmonary disease; clinical research; eicosanoids; human subject; inflammation; mass spectrometry; method development; necrosis; nucleosides; oxidative stress; patient oriented research; peptides; phenotype; phospholipids; proteins; pulmonary respiration; respiratory disease /disorder therapy; sample collection; spirometry; stable isotope; steroids; ultrafiltration

DESCRIPTION (provided by applicant): COPD is a world-wide health problem of increasing prevalence. Non-invasive markers of disease phenotype, severity and rate of progression of the disease, markers characterizing exacerbations of COPD are badly needed. We propose to analyze ultrafiltered exhaled air samples, to establish optimal protocols for sample collection following a FEV1 maneuver, to survey lipids including phospholipids, eicosanoids, steroids, nucleosides, proteins and peptides as markers of potential disease (activity). We propose to establish quantitative mass spectroscopic techniques (using stable isotope dilution protocols) for target marker assays. We propose to investigate stable COPD patients before and during supplemental continuous flow oxygen treatment, before and during alpha-l-antitrypsin infusion therapy, before and after smoking cessation and before and after lung transplantation.