PARTNERSHIP FOR RESEARCH & EDUCATION IN PLANTS

研究合作

• 批准号: 6804057
• 负责人: ERIN L DOLAN
• 金额: $ 30.52万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804057
• 关键词: Arabidopsis; biotechnology; clinical research; educational resource design /development; human subject; plant genetics; plant physiology; science education

The Fralin Biotechnology Center at Virginia Tech, in collaboration with university-based scientists and high school biology teachers, seeks support for developing (Phase I) and disseminating (Phase II) the Partnership for Research & Education in Plants (PREP). PREP was initiated at the request of high school students and their teachers, who wanted opportunities to collect 'real' science data, and scientists, who needed extra help in studying the 'white mouse' of the plant world, Arabidopsis thaliana. In an effort to better understand plant biology, scientists have sequenced the Arabidopsis genome. Now that the genome has been sequenced, emphasis is being placed on systematically identifying the function of an estimated 29,000 genes. One approach being taken is 'knocking out' each gene to determine its role in the growth, development, and physiology of the plant. This effort is creating an abundance of mutant plants, which must now be examined to determine each gene's function. In PREP, scientists provide wild-type and knock-out mutant seeds as well as experimental know-how to students as the students themselves design and conduct experiments to study the differences between wildtype plants and the previously uncharacterized mutants. Students then share their findings with PREP scientists at poster sessions and in lab reports. This partnership will continue to function as a collaboration with the following goals: to create a framework for sustainable partnerships between high school biology teachers, their students, and scientists; to share knowledge and research about biology; to provide students with opportunities to collect, analyze, draw conclusions about, and share real data; and to add to the body of data about genetics, genomics, and physiology, specifically of Arabidopsis thaliana. We propose to enhance and expand PREP in the following ways: improve student understanding of additional standards-based biology concepts (heredity and evolution, as well as ethical, legal, and social issues related to biotechnology) in the context of investigating wild-type and mutant Arabidopsis plants; increase the number of PREP scientist partners; enhance communication between geographically-separated PREP partners using web-based resources and technologies; disseminate PREP to a national audience via regional leadership centers and web-based approaches; and assess and describe the impact of PREP on participating teachers, students, and scientists.

弗吉尼亚理工大学弗拉林生物技术中心与大学科学家和高中生物教师合作，寻求支持以开发（第一阶段）和传播（第二阶段）植物研究与教育合作伙伴关系 (PREP)。 PREP 是应高中生和老师的要求发起的，他们希望有机会收集“真实”的科学数据，而科学家则需要额外的帮助来研究植物世界的“小白鼠”拟南芥。为了更好地了解植物生物学，科学家对拟南芥基因组进行了测序。现在基因组已完成测序，重点是系统地鉴定大约 29,000 个基因的功能。采取的一种方法是“敲除”每个基因以确定其在生长中的作用， 植物的发育和生理学。这项工作正在创造大量突变植物，现在必须对其进行检查以确定每个基因的功能。 在PREP中，科学家向学生提供野生型和敲除突变体种子以及实验知识，学生自己设计和进行实验来研究野生型植物和以前未表征的突变体之间的差异。然后，学生们在海报会议和实验室报告中与 PREP 科学家分享他们的发现。这种伙伴关系将继续发挥作用，实现以下目标：为高中生物教师、学生和科学家之间的可持续伙伴关系创建一个框架；分享生物学知识和研究；为学生提供收集、分析、得出结论和分享真实数据的机会；并添加有关遗传学、基因组学和生理学的数据，特别是拟南芥的数据。 我们建议通过以下方式加强和扩展 PREP： 在调查野生型和野生型的背景下，提高学生对其他基于标准的生物学概念（遗传和进化，以及与生物技术相关的伦理、法律和社会问题）的理解。突变拟南芥植物；增加 PREP 科学家合作伙伴的数量；利用基于网络的资源和技术加强地理上分散的 PREP 合作伙伴之间的沟通；通过区域领导中心和基于网络的方法向全国受众传播 PREP；并评估和描述 PREP 对 参与的教师、学生和科学家。