Molecular Regulation of CD8 T Cell Memory by BCL-6

BCL-6 对 CD8 T 细胞记忆的分子调节

• 批准号: 6738313
• 负责人: ERIC T CLAMBEY
• 金额: $ 4.73万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6738313
• 关键词: cell differentiation; cytotoxic T lymphocyte; gene induction /repression; genetically modified animals; immunologic memory; laboratory mouse; postdoctoral investigator; protein structure function; transcription factor

DESCRIPTION (provided by applicant): Following exposure to antigen, host lymphocytes go through a process of differentiation resulting in the generation of antigen-specific memory lymphocytes. Memory T cells provide a pool of antigen-specific lymphocytes capable of rapid response following antigen re-exposure. While T cell memory is beginning to be understood at the cellular level, the transcriptional regulation involved in memory is poorly understood. Recent genetic data have identified bcl-6, a sequence-specific transcriptional repressor, as a regulator of CD8 T cell memory. This proposal will focus on the role of bcl-6 in the generation of CD8 memory T cells, by defining the kinetics and function of bcl-6 in memory CD8 T cell development and survival. These studies will provide insight into the molecular regulation of CD8 T cell memory. Furthermore, they may identify specific methods to accentuate CD8 T cell memory to aid in clearance of infection, or to prevent inappropriate development of autoreactive CD8 memory T cells.

描述（由申请人提供）：暴露于抗原后，宿主淋巴细胞经历了分化的过程，从而导致抗原特异性记忆淋巴细胞的产生。记忆T细胞提供一组抗原特异性淋巴细胞，能够在抗原重新暴露后快速反应。尽管在细胞水平上开始了解T细胞记忆，但对记忆的转录调节的理解很少。最近的遗传数据已将BCL-6（序列特异性转录阻遏物）确定为CD8 T细胞存储器的调节剂。该建议将通过定义BCL-6在存储器CD8 T细胞发育和生存中的动力学和功能来定义BCL-6在CD8记忆T细胞产生中的作用。这些研究将洞悉CD8 T细胞记忆的分子调节。此外，他们可以确定特定的方法来强调CD8 T细胞存储器以帮助清除感染，或者防止自动反应性CD8记忆T细胞的不适当发展。