Primate Model of Drug Abuse: Gender and Hormonal Effects

药物滥用的灵长类动物模型：性别和激素影响

• 批准号: 6791919
• 负责人: MEGAN E ROTH
• 金额: $ 4.3万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6791919
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; biological models; cocaine; drug abuse; estrogen inhibitor; estrogens; gender difference; hormone regulation /control mechanism; inhalation drug abuse; menstrual cycle; methamphetamine; oral administration; phencyclidine; postdoctoral investigator; progesterone; psychopharmacology; reinforcer; self medication; smoking; substance abuse related behavior; tamoxifen

DESCRIPTION (provided by applicant): This proposal was designed to examine the effects of gender and menstrual cycle phase on oral and smoked drug self-administration in rhesus monkeys. A goal of the proposed experiments is to extend findings indicating gender and hormonal influences on drug abuse from rodent studies to nonhuman primates using experimental conditions similar to those that elucidate effects of these factors in rodents. Progressive ratio (PR) schedules and a behavioral economic analysis of demand will be used to evaluate the effects of gender and menstrual cycle phase on oral phencyclidine (PCP) and cocaine self-administration. The effects of gender on the escalation of cocaine intake will be examined using a differential access procedure that allows animals short- (1-hr) or long- (6-hr) access to drug self-administration. Following the differential access procedure, gender and menstrual phase differences in the reinforcing effectiveness of cocaine will be assessed using a PR schedule. A PR schedule and demand curve analysis will also be used to determine the relative reinforcing effectiveness of smoked cocaine and methamphetamine in males vs. females and during specific phases of the menstrual cycle.

描述（由申请人提供）： 该提案旨在研究性别和月经周期阶段对恒河猴口服和熏制药物自我给药的影响。拟议实验的一个目标是将性别和激素对药物滥用影响的发现从啮齿类动物研究扩展到非人类灵长类动物，使用类似于阐明这些因素对啮齿类动物影响的实验条件。渐进比例（PR）时间表和需求行为经济分析将用于评估性别和月经周期阶段对口服苯环己哌啶（PCP）和可卡因自我给药的影响。将使用差异化获取程序来检查性别对可卡因摄入量增加的影响，该程序允许动物短期（1小时）或长期（6小时）自我给药。在差异获取程序之后，将使用 PR 时间表来评估可卡因增强效果中的性别和月经阶段差异。 PR 时间表和需求曲线分析还将用于确定吸食可卡因和甲基苯丙胺对男性与女性以及月经周期特定阶段的相对增强效果。