MULTICHANNEL ARRAY TECHNIQUES: MULTICHANNEL RECORDING & ELECTRODES

多通道阵列技术：多通道记录

• 批准号: 6505241
• 负责人: DAVID JAMES ANDERSON
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6505241
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; ear; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

The placement of microprobes into deep brain structures such as hippocampus, Scarpa's ganglion, inferior colliculus, cochlear nucleus and deep cortical layers continues to be a growing area of interest for our external collaborators. Dr. Buzsaki's presentations at national meetings as well as his publications have stirred a great deal of interest from those recording in hippocampus. Challenges in using the probes for these preparations include holding the probe and maintaining a straight trajectory during insertion, accurate site placement in small regions well below the brain surface, and stabilization after insertion. We are working with the listed group of collaborative researchers to solve these problems. Probes with long shanks tend to bend during insertion. Several investigators are using cannular preparations to insert probes into deep structures. Others are exploring the coatings to enhance rigidity, or attachment of small, more rigid structures to the back of the substrate. New methods for insertion are also being evaluated for their ability to enhance the straightness of insertions. Custom probes have been designed by the above investigators and have been fabricated and provided by the Center mounted and bonded to desired connectors. The work done within this scientific sub-project benefits many investigators with new placement techniques, not only in deep brain structures but in other areas as well.

将微探针放置到大脑深层结构中，例如 海马、斯卡帕神经节、下丘、耳蜗核 深层皮质层仍然是人们日益感兴趣的领域 对于我们的外部合作者。 Buzsaki 博士的演讲 全国会议以及他的出版物引起了巨大的反响 海马体中的记录引起了人们的兴趣。 挑战 使用探针进行这些准备工作包括握住探针和 插入时保持直线轨迹，位置准确 放置在大脑表面以下的小区域，以及 插入后稳定。 我们正在与上市集团合作 合作研究人员来解决这些问题。 探头与 长柄在插入过程中容易弯曲。 多名调查人员正在 使用管状制剂将探针插入深层结构。 其他人正在探索涂层以增强刚性或附着力 基板背面的小型、更刚性的结构。 新的 插入方法也正在评估其能力 提高插入的直线度。 定制探针已 由上述研究人员设计并已制造和 由中心提供安装并粘合到所需的连接器。 这 这个科学子项目中所做的工作使许多人受益 研究人员不仅在大脑深处采用新的放置技术 结构，但在其他领域也是如此。