CHRONIC RECORDING USING SILICON MICROPROBES: CHRONIC IMPLANTS & MOTOR CORTEX

使用硅微探针进行慢性记录：慢性植入物

• 批准号: 6660151
• 负责人: JOHN C MIDDLEBROOKS
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660151
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

The most common application for which probes are requested is that of cortical recording. Although many different cortical areas are being explored (motor, visual, auditory), the preparations share similarities and problems which make collaborations with the Center and between external investigators increasingly important. Along with providing standard probes for acute cortical recording, the Center is working with collaborators (both institutional and corporate) to come up with probes, connectors, chamber designs and preparations for long-term implants. The challenges encountered in most of these preparations include placement of multiple devices into a single cranial chamber; maintaining positional stability of the probes; and inhibition of tissue encapsulation around the cable or 3-D platform due to healing of the cranium and dura. Several of the above collaborators continue to work on cranial chambers designed to hold several integrated cable/probes (either 2-D or 3-D) which protrude from the chamber edge into the cortical area. Some of the fixtures include a removable cap for access to the implants for inspection, cleaning and/or probe replacement. In the area of probe stability, collaborators are working with adhesives such as cyanoacrylate and fibrin glue to anchor the probes to the brain's surface. The University of Michigan Department of Materials Science and Engineering is also developing biological "glues" as well as materials which will inhibit tissue adhesion to apply to probe substrates. Surgical methods such as tenting of the dura over the probe insertions are being explored as well.

需要探针的最常见应用是 的皮质记录。 尽管许多不同的皮质区域 正在探索（运动、视觉、听觉），准备工作共享 与中心合作的相似点和问题 和外部调查员之间的关系变得越来越重要。 连同 该中心为急性皮质记录提供标准探针 与合作者（机构和企业）合作 包括探头、连接器、腔室设计和准备工作 长期植入物。 其中大部分遇到的挑战 准备工作包括将多个设备放置到一个单一的设备中 颅腔；保持探头的位置稳定性；和 抑制电缆或 3-D 平台周围的组织封装 由于颅骨和硬脑膜的愈合。 以上几项 合作者继续致力于设计用于容纳 多个突出的集成电缆/探头（2-D 或 3-D） 从腔室边缘进入皮质区域。 部分固定装置 包括一个可拆卸的盖子，用于检查植入物， 清洁和/或更换探头。 在探头稳定性方面， 合作者正在研究氰基丙烯酸酯等粘合剂 纤维蛋白胶将探针固定在大脑表面。 这 密歇根大学材料科学与工程系 还正在开发生物“胶水”以及能够 抑制组织粘附以应用于探针基底。 外科 诸如在探针插入处盖上硬脑膜等方法 也在探索之中。