Diet and Prostate Cancer Risk

饮食与前列腺癌风险

• 批准号: 6794948
• 负责人: JACKILEN SHANNON
• 金额: $ 15.92万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-25 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794948
• 关键词: biopsy; blood chemistry; cancer prevention; cancer risk; clinical research; computer data analysis; data collection methodology /evaluation; dietary lipid; gas chromatography; gene environment interaction; human subject; immunocytochemistry; nutrition related neoplasm /cancer; nutrition related tag; omega 3 fatty acid; prostaglandin E; prostaglandin endoperoxide synthase; prostate neoplasms; questionnaires; unsaturated fatty acids

DESCRIPTION (provided by applicant): The foundation of my career plan lies within a desire to build upon my solid background in nutritional epidemiology and cancer prevention with training and research experience in genetic epidemiology. My overall career goal is to establish a strong research program in diet and gene interactions in the prevention and progression of cancer, specifically prostate cancer and breast cancer. More immediately my goal is to develop a research agenda to assess the association between dietary fat and prostate cancer risk. This agenda will include a series of projects beginning with a case-control study to evaluate the association between dietary polyunsaturated fatty acid intake and prostate cancer risk and to determine whether polyunsaturated fatty acids function through the cyclooxygenase pathway to alter prostate cancer risk. This research project, in addition to being scientifically stimulating also provides me with an opportunity to work closely with geneticists, genetic epidemiologists, and oncologists to develop my knowledge and practical skills in genetic epidemiology. The Oregon Health Sciences University (OHSU) provides an ideal environment for pursuing this research agenda. OHSU together with the Oregon Cancer Institute have a clear interest in supporting cancer prevention and control research. My particular area of interest ties in well with an established program in Molecular Biology and Genetics as well as with the research interests of other established investigators at OHSU. The Public Health Preventive Medicine program provides senior collaborators in epidemiology and biostatistics as well as staff support. OHSU is physically located adjacent to the Portland VA Medical Center, providing OHSU researchers the unique opportunity to collaborate with VA researchers, and access to a large and well-described population of individuals.

描述（由申请人提供）：我的职业计划的基础是渴望以我在营养流行病学和癌症预防的坚实背景下，并通过遗传流行病学方面的培训和研究经验。 我的整体职业目标是在癌症的预防和进展方面建立强大的饮食和基因相互作用研究计划，特别是前列腺癌和乳腺癌。 更立即，我的目标是制定研究议程，以评估饮食脂肪和前列腺癌风险之间的关联。 该议程将包括一系列项目，首先是一项病例对照研究，以评估饮食多不饱和脂肪酸的摄入和前列腺癌风险之间的关联，并确定多不饱和脂肪酸是否通过环氧酶途径来改变前列腺癌风险。 除了科学刺激外，该研究项目还为我提供了与遗传学家，遗传流行病学家和肿瘤学家紧密合作的机会，以发展我的遗传流行病学知识和实践技能。 俄勒冈健康科学大学（OHSU）为追求这一研究议程提供了理想的环境。 OHSU与俄勒冈州癌症研究所一起对支持癌症的预防和控制研究具有明显的兴趣。 我的特定感兴趣领域与一项既定的分子生物学和遗传学方案以及OHSU其他既定研究者的研究兴趣联系在一起。 公共卫生预防医学计划为流行病学和生物统计学以及员工支持提供了高级合作者。 OHSU物理位于波特兰VA医疗中心附近，为OHSU研究人员提供了与VA研究人员合作的独特机会，并获得了大量且描述良好的个人人群。