Acquisition of a Small Animal CT Scanner

购置小动物 CT 扫描仪

• 批准号: 6580702
• 负责人: RICHARD Andre LAFOREST
• 金额: $ 39.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580702
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; computed axial tomography

DESCRIPTION (provided by applicant): Small animal imaging has become a powerful tool for drug development and for the understanding of diseases. With animal models widely used in basic and pre-clinical sciences, finding ways to conduct animal experiments more accurately and efficiently is now a key factor in the success and timeliness of research. The recent evolution in molecular biology and genomics has created a large demand for transgenic laboratory animals. In oncology, the use of radiopharmaceuticals for the non-invasive diagnosis of cancer has long been established. And now, small animal PET imaging is being used extensively for tumor targeting by the use of metabolic, transport and receptor-mediated processes to deliver the imaging agent for cancer diagnostic in tumor bearing small animal. The use of high resolution microCT images will augment the performance of functional imaging currently obtained with our microPET by providing accurate identification and localization of normal organ or tumor volume. The combined technologies will allow for the study of disease progression in longitudinal studies and response to therapy over time. Other applications, including pulmonary, cardiology, immunology and orthopedic surgery will all benefit from higher resolution anatomical information. These images will also be used to improve the quality of functional images by providing an accurate attenuation correction. This proposal from Washington University, School of Medicine, is to request funds for the purchase of a 40 micron spatial resolution small animal X-ray CT camera. This instrument will be made available to researchers of many disciplines at Washington University.

描述（由申请人提供）： 小动物成像已成为药物开发和理解疾病的有力工具。借助广泛用于基本和临床前科学中的动物模型，现在可以更准确，更有效地寻找动物实验的方法是研究成功和及时性的关键因素。分子生物学和基因组学的最新演变对转基因实验动物产生了巨大的需求。在肿瘤学中，长期以来已经建立了放射性药物对癌症的非侵入性诊断的使用。现在，通过使用代谢，运输和受体介导的过程将小动物宠物成像广泛用于肿瘤靶向，以在带有小动物的肿瘤中提供癌症诊断的成像剂。使用高分辨率MicroCT图像的使用将通过提供正常器官或肿瘤体积的准确鉴定和定位来增强使用MicroPET获得的功能成像的性能。合并的技术将允许在纵向研究中研究疾病进展，并随着时间的推移对治疗的反应。其他应用，包括肺部，心脏病学，免疫学和骨科手术，都将受益于更高分辨率的解剖信息。这些图像还将通过提供准确的衰减校正来改善功能图像的质量。华盛顿大学医学院的这项建议是要求购买40微米的空间分辨率小动物X射线CT摄像头。该乐器将提供给华盛顿大学许多学科的研究人员。