Applied Biosystems QStar Pulsar I with oMALDI Source

Applied Biosystems QStar Pulsar I 与 oMALDI 源

• 批准号: 6578612
• 负责人: Jeffrey W Smith
• 金额: $ 48.81万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578612
• 关键词: biomedical equipment purchase; high throughput technology; mass spectrometry; matrix assisted laser desorption ionization; proteomics

DESCRIPTION (provided by applicant): The Burnham Institute requests funding for the acquisition of an Applied Biosystems Q-Star Pulsar I mass spectrometer with an orthogonal MALDI sample introduction source. This is a modern state-of-the-art tandem mass spectrometer that has enhanced capabilities in terms of speed of analysis, sensitivity, automation, high-throughput, mass accuracy and mass resolution that cannot be met with existing instrumentation. The requested instrument will support an NIH funded user group conducting research across many therapeutic areas including cancer, allergy and inflammation, neurodegenerative disorders and cardiovascular disease. Many of these investigators have previous experience applying protein mass spectrometry analysis to their research programs. All will benefit from the technological enhancements the requested instrument provides. The Q-Star will be will be integrated, into the Institute's Molecular Analysis Facility, an established proteomics core facility. The instrument will be maintained and operated under the direction of a full-time Ph.D. level Director. Knowledge gained from the use of the Q-Star will be disseminated to the broader scientific community. Access to the mass spectrometer will be made available to scientists outside the major user group. The acquisition of the Q-Star instrument will enhance the Burnham Institute's broad, long-term effort of supporting and enabling world-class science at the interface of biology and mass spectrometry.

描述（由申请人提供）：伯纳姆研究所要求获得具有正交MALDI样本简介资料来源的Applied Biosystems Q-Star Pulsar I质谱仪的资金。这是一种现代的最先进的串联质谱仪，在分析速度，灵敏度，自动化，高通量，质量准确性和质量分辨率方面具有增强的功能，无法与现有仪器相满足。该请求的仪器将支持NIH资助的用户组，该用户组在许多治疗领域进行研究，包括癌症，过敏和炎症，神经退行性疾病和心血管疾病。这些研究人员中的许多人以前具有将蛋白质质谱分析应用于其研究计划的经验。所有这些都将受益于要求的仪器提供的技术增强功能。 Q-Star将被整合到该研究所的分子分析设施中，这是一个已建立的蛋白质组学核心设施。该仪器将在全职博士学位的指导下进行维护和运作。水平主任。从使用Q-Star获得的知识将被传播到更广泛的科学界。主要用户组以外的科学家将获得质谱仪的访问。 Q-Star工具的获取将增强Burnham Institute在生物学和质谱界面上支持和实现世界一流科学的艰巨而长期的努力。