TRAINING GRANT ON THE BIOLOGY OF AGING

衰老生物学培训补助金

• 批准号: 6593002
• 负责人: OLIVIA M. PEREIRA-SMITH
• 金额: $ 57.29万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6593002
• 关键词: TRAINING; GRANT; BIOLOGY; AGING

DESCRIPTION (provided by applicant): This application is a new training program for research scientists in the areas of genetics of aging, lifespan intervention analyses in animal models, and age-related diseases. Pre- and post-doctoral fellows (10 and 6 per year respectively) will be trained in the biology of aging. The trainees will participate in projects involving: programmed changes in gene expression; somatic mutations and epigenetic changes in gene expression; free radicals, DNA damage and DNA repair; aging of endocrine and immune systems; transmembrane signaling; oncogenes and tumor suppressor genes in cell growth, differentiation and apoptosis; and the molecular aspects of age-associated diseases such as Alzheimer's disease, Parkinson's disease and prostatic hyperplasia and neoplasia. The Biology of Aging course and journal clubs on current topics in gerontology will provide the formal setting for didactic training. The Aging Seminar Series will be the focal point of interactions of the trainees with eminent scientists working in the field of aging. Trainees will be selected based on their interest in aging, academic excellence, and motivation for careers in research, instruction and service as reflected from their academic records, and letters of recommendations. The Institutional core facilities for generating transgenic mice, biometry, recombinant DNA technology, hybridoma, flow cytometry microassay and confocal microscopy will be available to all trainees and the participating faculty. This program is comprised of 27 faculty trainers of whom 22 are funded by the NIA. Two are newly recruited Assistant Professors with a clear interest in aging. The three senior investigators with other funding are interested in aging, involved in teaching in the Aging course, and participating in the journal club, and provide research interests that add to, rather than duplicate, that of the other trainers. As a result, the trainees will have a broad range of research to choose from and they will work with individuals who have demonstrated their training ability. San Antonio has the unique situation of having access to and recruiting minorities from the undergraduate universities in the area, e.g., University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future.

描述（由申请人提供）：本申请是针对衰老，动物模型中寿命干预分析和与年龄相关疾病的遗传学领域的研究科学家的新培训计划。博士后研究员（每年分别为10和6）将接受衰老的生物学培训。 学员将参加涉及的项目：基因表达的程序更改；基因表达的体细胞突变和表观遗传变化；自由基，DNA损伤和DNA修复；内分泌和免疫系统的老化；跨膜信号传导；细胞生长，分化和凋亡中的癌基因和肿瘤抑制基因；以及年龄相关疾病的分子方面，例如阿尔茨海默氏病，帕金森氏病和前列腺增生和肿瘤。老龄化课程的生物学和关于老年学主题的期刊俱乐部将为教学培训提供正式环境。衰老研讨会系列将是学员与在衰老领域工作的知名科学家相互作用的焦点。学员将根据他们对衰老，学术卓越的兴趣和研究，教学和服务职业的兴趣，从他们的学术记录和推荐信中反映出来。生成转基因小鼠，生物特征，重组DNA技术，杂交瘤，流式细胞仪微测和共聚焦显微镜的机构核心设施将提供给所有受训者和参与的教职员工。该计划由27名教师培训师组成，其中22名由NIA资助。两人是新招募的助理教授，对衰老有清晰的兴趣。拥有其他资金的三名高级调查员对老化感兴趣，参与老龄化课程的教学以及参加期刊俱乐部，并提供研究兴趣，而不是复制其他培训师的兴趣。结果，学员将有广泛的研究可供选择，他们将与表现出训练能力的个人合作。圣安东尼奥有独特的情况，即从该地区的本科大学，例如得克萨斯大学圣安东尼奥大学和圣玛丽大学访问和招募少数民族。只要做到这一点，就会做出巨大的努力。对该计划的支持具有培训急需的科学家群体的所有潜力；未来的老年生物学家。