Facial and Dental Arch Growth Following Palatal Surgery

腭手术后面部和牙弓的生长

• 批准号: 6807594
• 负责人: WILLIAM N WILLIAMS
• 金额: $ 44.38万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6807594
• 关键词: bone development; cleft palate; clinical research; congenital oral /facial /cranial defect; dental development; dentistry; dentition; facial bones; human subject; longitudinal human study; mandible /maxilla; middle childhood (6-11); oral pharyngeal surgery; palate; speech

DESCRIPTION: The incidence of cleft lip/palate is approximately 1/750, making it one of the most common congenital malformations. The primary goal in surgically repairing the palatal cleft is to construct a velopharyngeal port capable of supporting normal non-nasal speech without impairing growth of the face or Dental arches. Adults with unrepaired cleft lip and palate rarely have the recessed midface that too often characterizes the profile of adults whose cleft lip and palate have been repaired in infancy. Factors associated with the surgery are likely the major cause of midface growth disturbance. The University of Florida, in collaboration with the University of Sao Paulo, Bauru, Brazil, is proposing a longitudinal study to determine whether children between 6 and 10 years of age, born with complete unilateral cleft lip and palate, have different facial and/or Dental arch relationships as a function of the surgical techniques used in repairing their lip and/or palate, and/or as a function of their age when they received palatal surgery. This study proposes to enroll the entire patient pool of 475 patients who currently are subjects in an ongoing NIDCR sponsored study in which speech and velopharyngeal outcome measures are being assessed relative to the surgical techniques subjects underwent. Subjects were randomly assigned for lip surgery (Spina vs. Millard technique), palatal surgery (von Langenbeck vs. Furlow procedure), and age of palatal repair (9-12 months vs. 15-18 months). The proposed study will provide data defining the maxillary growth and Dental arch relationships in this very large group of patients, from which conclusions should be possible regarding the relative importance of the Millard or Spina lip repair and the von Langenbeck palatoplasty or the double opposing z-plasty palate repair on facial and Dental arch growth. A secondary part of the study will be a long-term follow-up of velopharyngeal function for speech.

描述：唇裂/腭裂的发病率约为 1/750，使其成为最常见的先天畸形之一。手术修复腭裂的主要目标是构建一个能够支持正常非鼻言语而不损害面部或牙弓生长的腭咽口。唇裂和腭裂未修复的成年人很少会出现中面部凹陷的情况，而这种情况往往是唇裂和腭裂在婴儿期修复过的成年人的特征。与手术相关的因素可能是中面部生长障碍的主要原因。佛罗里达大学与巴西巴乌鲁圣保罗大学合作，提议开展一项纵向研究，以确定出生时患有完全性单侧唇裂和腭裂的 6 至 10 岁儿童是否具有不同的面部和/或面部特征。牙弓关系是修复嘴唇和/或腭所使用的手术技术的函数，和/或是接受腭手术时年龄的函数。这项研究拟将 475 名患者全部纳入其中，这些患者目前是 NIDCR 资助的一项正在进行的研究的受试者，该研究正在根据受试者所接受的手术技术来评估言语和腭咽结果测量。受试者被随机分配接受唇部手术（Spina 与 Millard 技术）、腭手术（von Langenbeck 与 Furlow 手术）和腭修复年龄（9-12 个月与 15-18 个月）。拟议的研究将提供定义这一庞大患者群体的上颌生长和牙弓关系的数据，从中可以得出有关 Millard 或 Spina 唇部修复术以及 von Langenbeck 腭成形术或双相对 z- 相对重要性的结论。面部和牙弓生长的整形腭修复。该研究的第二部分将是对腭咽言语功能的长期随访。