Non-invasive blood glucose monitor

无创血糖监测仪

• 批准号: 6834956
• 负责人: Igor E Trofimov
• 金额: $ 9.99万
• 依托单位: PTAC, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834956
• 关键词: biochemistry; blood glucose; fiber optics; hospitals; infrared spectrometry; lasers; patient monitoring device; semiconduction; technology /technique development

DESCRIPTION (provided by applicant): The proposed program will develop a novel near-infrared laser based spectrophotometer suitable for transcutaneous determination of blood glucose. Non-invasive blood glucose monitors that utilize conventional spectrometers and thermal light sources suffer from insufficient signal-to-noise ratio for the stable prediction of glucose concentration. The laser-based system we propose to develop and test is expected to exhibit superior signal-to-noise measurements of glucose, and therefore better sensitivity and specificity. These in turn will provide a better account for physiological and phenotypic variables. The proposed technology has the significant advantage over other approaches of being based upon an inherently miniaturizable, power-efficient, and mechanically stable technology that will permit the development of a compact robust system. This technology promises to produce a fundamental improvement in the frequency with which diabetic patients monitor their blood glucose. It will have a major impact on the public health issues arising from diabetes. Phase I of this project will determine the feasibility of the proposed approach by in-vitro measurements of clinical samples of whole blood. During Phase II of this project a prototype of a hand-held in-vivo monitor based upon the system engineered in Phase I will be constructed, and clinical trials will be conducted. Total diabetes glucose self-monitoring devices market for the U.S. alone was valued at $1.2 billion. There are number of industries that this technology could provide benefits. Besides obvious applications in medical devices for glucose measurements, and monitoring other metabolites in human body, it can be used in food and pharmaceutical industries, as well as for environmental monitoring and industrial safety.

描述（由申请人提供）： 拟议的计划将开发一种新型近红外激光分光光度计，适用于经皮测定血糖。使用传统光谱仪和热光源的无创血糖监测仪的信噪比不足，无法稳定预测葡萄糖浓度。我们建议开发和测试的基于激光的系统预计将表现出优异的葡萄糖信噪比测量，因此具有更好的灵敏度和特异性。这些反过来将为生理和表型变量提供更好的解释。所提出的技术比其他方法具有显着的优势，因为它基于本质上可小型化、节能且机械稳定的技术，这将允许开发紧凑的鲁棒系统。这项技术有望从根本上提高糖尿病患者监测血糖的频率。它将对糖尿病引起的公共卫生问题产生重大影响。 该项目的第一阶段将通过全血临床样本的体外测量来确定所提出方法的可行性。在该项目的第二阶段，将构建基于第一阶段设计的系统的手持式体内监测仪原型，并进行临床试验。 仅美国的糖尿病血糖自我监测设备市场总额就达到 12 亿美元。 这项技术可以为许多行业带来好处。除了在医疗设备中用于葡萄糖测量和监测人体内其他代谢物外，它还可以用于食品和制药行业，以及环境监测和工业安全。