Extinction: The Neural Mechanisms of Behavior Change

灭绝：行为改变的神经机制

• 批准号: 6887943
• 负责人: Gregory J Quirk
• 金额: $ 7.44万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887943
• 关键词: Puerto Rico; behavioral extinction; cooperative study; meeting /conference /symposium; neuropsychology; travel

DESCRIPTION (provided by applicant): This proposal is for a one-time scientific conference entitled, "Extinction: The Neural Mechanisms of Behavior Change", to be held in Ponce, Puerto Rico, February 2-6, 2005. Extinction is the decreased expression of conditioned responding that occurs when a conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus. Deficits in extinction learning are thought to underlie anxiety disorders (such as PTSD) and addictive behavior, both of which involve persistent emotional responses that are no longer appropriate. Understanding the neural mechanisms of extinction could lead to novel behavioral and pharmacological therapies. This would be the first conference ever held on the topic of extinction, a new field which has undergone rapid growth in the past 4 years. This is a unique opportunity to bring together the entire field of researchers (32 basic and clinical scientists) to resolve controversies and encourage a translational approach for future research. The conference will consist of 8 sessions: 1) Amygdala mechanisms in extinction of aversive conditioning, 2) Prefrontal mechanisms in extinction of aversive conditioning, 3) Contextual modulation of extinction, 4) Molecular mechanisms of extinction: Prefrontal-amygdala system, 5) Molecular mechanisms of extinction: Other systems, 6) Extinction of appetitive conditioning and addiction, 7) Neural substrate of extinction in humans, 8) Extinction as a therapeutic tool. Each session will be followed by questions from local students and an extended general discussion. Therewill also be evening debates on controversial themes, and a poster session. The conference will have a high degree of women & minority participation at all levels (speakers, organizing committee, attendees), and will provide students in Puerto Rico with unprecedented access to experts in the field. Travel fellowships for students from neighboring countries in Latin America will be provided. The findings will be disseminated in a special issue of the journal Biological Psychiatry, which will reach those most interested in the translational focus of the meeting. Thus, the conference should have considerable scientific impact, as well as serving a capacity-building function in the region.

描述（由申请人提供）：该提议是针对一次性科学会议，标题为“灭绝：行为改变的神经机制”，将在波多黎各的庞塞举行，2005年2月2日至6日。灭绝学习中的缺陷被认为是焦虑症的基础（例如PTSD）和成瘾行为，这两者都涉及不再适当的持续情感反应。了解灭绝的神经机制可能导致新型的行为和药理疗法。这将是有史以来第一次关于灭绝话题的会议，这是一个新领域，在过去的四年中，它经历了快速增长。这是将整个研究人员（32位基本和临床科学家）汇集在一起​​的独特机会，以解决争议并鼓励转化方法进行未来的研究。会议将包括8个会议：1）抗厌恶调节的杏仁核机制，2）灭绝厌恶条件的前额叶机制，3）3）灭绝的上下文调节，4）灭绝分子机制：前额叶 - amygdala 系统，5）灭绝的分子机制：其他系统，6）灭绝调节和成瘾的灭绝，7）人类灭绝的神经底物，8）灭绝作为治疗工具。每次会议都会有当地学生的问题和广泛的一般讨论。因此，还将在有争议的主题和海报会议上进行晚间辩论。该会议将在各个级别（演讲者，组织委员会，与会者）中有高度的妇女和少数派参与，并将为波多黎各的学生提供前所未有的与该领域专家的机会。将为来自拉丁美洲邻国的学生提供旅行奖学金。这些发现将在《生物精神病学》杂志的特刊中传播，该杂志将吸引那些对会议转化重点最感兴趣的人。因此，会议应具有相当大的科学影响，并在该地区发挥能力建设功能。