Treating antisocial youth: brain and behavioral changes

治疗反社会青少年：大脑和行为的改变

• 批准号: 6666904
• 负责人: DEBRA J. PEPLER
• 金额: $ 14.58万
• 依托单位: YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6666904
• 关键词: adolescence (12-20); antisocial personality; attention; behavior modification; behavior test; behavior therapy; behavioral /social science research tag; child psychology; cingulate gyrus; clinical research; cognition; electroencephalography; evoked potentials; frontal lobe /cortex; gender difference; human subject; human therapy evaluation; interdisciplinary collaboration; journals; meeting /conference /symposium; neuropsychology; parent offspring interaction; peer group; racial /ethnic difference; social psychology; technology /technique development

DESCRIPTION (provided by applicant): The proposed interdisciplinary research network is designed to examine the neural and behavioral changes that underpin successful treatment outcomes for antisocial adolescents. There are four specific aims: (1) to create a multi-site network that can support collaborations among scientists and practitioners from diverse disciplines interested in clinical change; (2) to explore microsocial processes of behavioral regulation in the family and peer systems, and neurocognitive mechanisms responsible for shifting attention and controlling impulses, that correspond to successful clinical interventions; (3) to test and refine new temporally sensitive methods that can tap fine-grained changes in brain (dense-array ERP methods) and behavior (dynamic real-time behavior maps); and (4) to identify the characteristics of youth for whom evidence-based treatments are effective and model the processes that underlie successful outcomes for different antisocial subtypes. Plans for building and supporting the Network infrastructure include full-team meetings, meetings among clusters of network members, workshops and a mini-conference to share information with the broader scientific and clinical community, collaborations for generating pilot research, and collaborations for manuscript preparation and development of major research proposals. The planned pilot studies will draw on the diverse expertise of team members to fashion innovative approaches to brain and behavioral assessment. Behavioral assessment will target changes in overall behavioral flexibility and stability of negative patterns. Neural assessment will target changes in ERP signatures of attentional regulation and response selection. Global predictions are that both sets of changes will correspond with clinical improvement as assessed by more conventional outcome measures. The overall goals are to advance knowledge about the causal substrates of antisocial patterns and the mechanisms underlying treatment success, and to disseminate new evaluation techniques to clinicians interested in monitoring treatment progress.

描述（由申请人提供）：拟议的跨学科研究网络旨在检查支持反社会青少年成功治疗结果的神经和行为变化。有四个具体目标：（1）创建一个多站点网络，可以支持对临床变化感兴趣的不同学科的科学家和从业者之间的合作； (2) 探索家庭和同伴系统中行为调节的微观社会过程，以及负责转移注意力和控制冲动的神经认知机制，这与成功的临床干预相对应； (3) 测试和完善新的时间敏感方法，这些方法可以挖掘大脑（密集阵列 ERP 方法）和行为（动态实时行为图）的细粒度变化； (4) 确定循证治疗有效的青少年的特征，并模拟不同反社会亚型成功结果的过程。建设和支持网络基础设施的计划包括全团队会议、网络成员集群之间的会议、研讨会和小型会议，以便与更广泛的科学和临床界共享信息、开展试点研究的合作以及手稿准备和出版的合作。制定重大研究计划。计划中的试点研究将利用团队成员的多元化专业知识，形成大脑和行为评估的创新方法。行为评估将针对整体行为灵活性和负面模式稳定性的变化。神经评估将针对注意力调节和反应选择的 ERP 特征的变化。全球预测是，两组变化都将与通过更传统的结果指标评估的临床改善相对应。总体目标是增进对反社会模式的因果基础和治疗成功的机制的了解，并向有兴趣监测治疗进展的临床医生传播新的评估技术。