Longitudinal Twin Study of Reading Disability

阅读障碍的纵向双胞胎研究

• 批准号: 6708385
• 负责人: SALLY J WADSWORTH
• 金额: $ 25.73万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6708385
• 关键词: attention deficit disorder; behavioral /social science research tag; clinical research; comorbidity; disease /disorder etiology; dizygotic twins; gene environment interaction; human subject; longitudinal human study; monozygotic twins; patient oriented research; psychometrics; psychopathology; reading disorder; siblings; twin /multiplet

DESCRIPTION (provided by applicant): The proposed project will initiate the first longitudinal twin study of reading disability and conduct novel analyses of the genetic and environmental etiologies of stability and change in reading difficulties. To accomplish these objectives, an extensive psychometric test battery, as well as behavioral questionnaires and interviews, will be administered to a sample of 50 pairs of identical twins and 50 pairs of fraternal twins in which at least one member of each pair is reading disabled, to their siblings, and to a comparison sample of 50 pairs of identical twins and 50 pairs of fraternal twins with no history of reading deficits, all of whom previously participated in the Colorado Learning Disabilities Research Center CLDRC). Resulting data will be analyzed in conjunction with data previously collected in the CLDRC to provide the first longitudinal assessment of the genetic and environmental etiologies of reading deficits and subtypes of reading disability at two ages, as well as their longitudinal stability and comorbidity with ADHD. These data will also be used to test novel hypotheses about the longitudinal covariation of reading difficulties with measures of other psychopathology, reading, language and perceptual processes and specific cognitive abilities. Univariate and bivariate QTL analyses of reading deficits and ADHD, reading component processes and other psychopathology will also be conducted.

描述（由申请人提供）：拟议的项目将启动 第一次纵向双胞胎读数障碍和进行新分析 稳定性和阅读变化的遗传和环境病因 困难。为了实现这些目标，广泛的心理测验 电池以及行为问卷和访谈将是 给予50对相同双胞胎和50对的样本 兄弟双胞胎，其中至少有一个成员正在禁用读书， 到他们的兄弟姐妹，以及50对相同双胞胎的比较样本 还有50对没有阅读缺陷史的兄弟双胞胎，所有 以前参加了科罗拉多学习障碍研究 中心CLDRC）。结果数据将与数据结合分析 以前在CLDRC中收集以提供第一个纵向评估 阅读缺陷和亚型的遗传和环境病因 在两个时代阅读障碍及其纵向稳定性和 与多动症合并症。这些数据也将用于检验新假设 关于阅读困难的纵向协调 其他心理病理学，阅读，语言和感知过程以及特定的 认知能力。单变量和双变量QTL分析的阅读缺陷分析 和多动症，阅读组件过程和其他心理病理学也将是 实施。