CORE GRANT FOR VISION RESEARCH

愿景研究核心资助

• 批准号: 6384893
• 负责人: Dianna Ammons Johnson
• 金额: $ 16.86万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6384893
• 关键词: biomedical facility; health science research support; vision

Having established the Center for Vision Research and The Ophthalmology Institute within the past two years, The University of Tennessee, Memphis, is providing major resources to support vision research. Part of the expanded support is reflected in the growth of the Department of Ophthalmology which has gained several basic and clinical scientist over the past four years. This expansion complements a strong vision research group within the Departments of Anatomy and Neurobiology, and Physiology, as well as investigators at two neighboring institutions-St. Jude Children's Research Hospital and Southern College of Optometry. At present, over 20 active vision scientists with funded research programs participate in the Center for Vision Research. To enhance ongoing NEI-supported programs, four core modules that each serve active facets of our group's research will be supported. The Imaging Module contains a high-resolution digital image analysis system for light microscopy, a rapid-response calcium imaging system, an inverted fluorescence photomicroscope, and a state-of the-art motorized cryostat. The Molecular Biology Module provides automated DNA sequencing and genotyping, quantitative real-time PCR, and gene array chip scanning technology. The Cell Biology Module provides a central facility for acquiring, storing, and culturing human donor tissues and human cell lines for morphologica1, biochemical, and genetic analysis. The Bioinformatics Module assists in computer-based database management, biostatistical analyses, Internet publication of large datasets, high level software support for image analysis and genomics, and basic research design and interpretation. Modules are housed within the newly established Ophthalmology Institute and in the Neuroscience Institute, allowing easy access to all research groups. Strong institutional support has been pledged for this effort and includes a total outlaw of $250,000 for equipment, technical support, and instrument service contract.

田纳西大学孟菲斯分校在过去两年内建立了视觉研究中心和眼科研究所，正在为支持视觉研究提供主要资源。 扩大的支持部分反映在眼科的发展上，该科在过去四年中获得了多名基础和临床科学家。这一扩展补充了解剖学、神经生物学和生理学系内强大的视觉研究小组，以及两个邻近机构（圣路易斯大学）的研究人员。圣裘德儿童研究医院和南方视光学院。目前，视觉研究中心有超过 20 名拥有资助研究项目的活跃视觉科学家参与。为了加强正在进行的 NEI 支持的项目，将支持四个核心模块，每个模块都服务于我们小组研究的活跃方面。成像模块包含用于光学显微镜的高分辨率数字图像分析系统、快速响应钙成像系统、倒置荧光显微镜和最先进的电动低温恒温器。分子生物学模块提供自动化DNA测序和基因分型、定量实时PCR和基因阵列芯片扫描技术。细胞生物学模块提供了一个中央设施，用于获取、存储和培养人类供体组织和人类细胞系，以进行形态学、生化和遗传分析。生物信息学模块协助基于计算机的数据库管理、生物统计分析、大型数据集的互联网发布、图像分析和基因组学的高级软件支持以及基础研究设计和解释。模块位于新成立的眼科研究所和神经科学研究所内，可以轻松访问所有研究小组。我们已承诺为此努力提供强有力的机构支持，其中包括总计 25 万美元的设备、技术支持和仪器服务合同。