METHODS FOR EVALUATING VACCINE EFFICACY

评估疫苗功效的方法

• 批准号: 2066945
• 负责人: Michael J Haber
• 金额: $ 15.28万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2066945
• 关键词: communicable disease transmission; computer program /software; disease /disorder proneness /risk; epidemiology; human data; human therapy evaluation; mathematical model; method development; statistics /biometry; vaccines

The broad, long-term objective is the development of analytic and statistical methods for the evaluation of interventions in infectious diseases. The specific aim is to develop analytic and statistical methods for evaluating efficacy of vaccines and effectiveness of vaccination programs against acute, directly transmitted infectious agents, such as acute, respiratory-related illnesses, given: heterogenous susceptibility of the target population, heterogenous action of the vaccine within the target population, different conditions of non-random mixing and transmission of infection, and vaccines that confer different types of protection, such as against infection or disease, or that reduce infectiousness. The experimental design and methods consist of: theoretical development and comparison of vaccine efficacy estimators and their standard errors based on: attack rates and transmission rates for randomly mixing populations, secondary attack rates for non-randomly mixing populations various methods of estimation, including maximum likelihood, log-linear models, least squares, martingales, and bootstrap, simulations using deterministic and stochastic models, analysis of data provided by the Immunization Branch of the CDC and the Task Force for Child Survival of the Carter Center.

广泛的长期目标是分析和 评估传染性干预措施的统计方法 疾病。 具体目的是开发分析和统计方法 评估疫苗的功效和疫苗接种计划的有效性 反对急性，直接传播感染剂，例如急性， 给出了与呼吸有关的疾病： 目标人群的异源敏感性， 疫苗在目标人群中的异质作用， 非随机混合和感染传播的不同条件， 以及提供不同类型保护的疫苗，例如 感染或疾病，或减少感染性。 实验设计和方法包括： 疫苗功效估计器和比较的理论发展和比较 他们的标准错误基于： 随机混合种群的攻击率和传输速率， 非随机混合种群的次要攻击率 各种估计方法，包括最大似然，对数线性 型号，最小二乘，防护和引导程序， 使用确定性和随机模型的模拟， 分析CDC和CDC的免疫分支提供的数据 卡特中心儿童生存工作队。