Trace elements among Iowa pesticide applicators

爱荷华州农药施用者中的微量元素

• 批准号: 6768803
• 负责人: LESLIE K DENNIS
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6768803
• 关键词: activation analysis; agriculture worker; arsenic; atomic absorption spectrometry; biomarker; cadmium; chemical related neoplasm /cancer; clinical research; dietary trace element; environment related neoplasm /cancer; environmental exposure; environmental toxicology; human subject; male; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; pesticide biological effect; pesticide residues; prostate neoplasms; prostate specific antigen; questionnaires; selenium; skin absorption; skin derivative

DESCRIPTION (provided by applicant): The Agricultural Health Study (AHS) is an established, on-going prospective cohort study examining the relationship between agricultural exposures, such as pesticide use, and disease among applicators in Iowa and North Carolina. The AHS in Iowa involves 36,793 licensed pesticide applicators, plus 21,773 spouses who are exposed either directly or indirectly to pesticides and other agricultural exposures. Prostate cancer incidence and mortality are higher among farmers, making this a high-risk cohort. The mechanism of potential exposure among farmers is unclear, so research into this subgroup of Americans is important. Current literature suggests associations with prostate cancer and arsenic, cadmium and low selenium levels but studies have not been consistent. We propose a nested case-control pilot study of incident prostate cancer within the existing AHS, identified through semi-rapid reporting of prostate cancers by the Iowa Cancer Registry (ICR), to examine trace elements found in toenails including arsenic, cadmium and selenium, all long-lived indicators, along with other trace elements that fit into this classification. We will compare these elements in 86 incident prostate cancer cases to 172 controls (frequency matched on age, completion of the diet survey, and a recent PSA test) from within the AHS cohort. We will use neutron activation analysis (NAA) to analyze for the targeted trace elements. We justify examining the other trace elements as a cost efficient, hypothesis generating sub-study. A secondary aim of this pilot study is to examine the validity of arsenic and selenium measured in toenails compared with standard questionnaire measurements of dietary selenium and arsenic pesticides collected prior to diagnosis in this cohort. In residentially stable populations, biomarkers of trace elements may be a good measure of exposure reducing the need for questionnaires with long detailed lists of pesticides and complex food frequency questionnaires (FFQs).

描述（由申请人提供）： 农业健康研究（AHS）是一项既定的，正在进行的前瞻性队列研究，研究了爱荷华州和北卡罗来纳州的施加者之间农业暴露之间的关系，例如农药使用和疾病。爱荷华州的AHS涉及36,793名许可的农药施用者，以及21,773名配偶，直接或间接暴露于农药和其他农业暴露。农民的前列腺癌发病率和死亡率更高，使其成为高风险队列。农民潜在暴露的机制尚不清楚，因此对这一亚组的美国人的研究很重要。当前的文献表明，前列腺癌和砷，镉和低硒水平的关联，但研究并不一致。 我们提出了一项嵌套的病例对照试验性研究现有AHS中的事件前列腺癌，通过爱荷华州癌症登记局（ICR）对前列腺癌的半比例报告，检查在木术中发现的痕量元素，包括砷，镉和硒，以及所有长期存在的痕量元素，以及所有这些痕量元素，以及这些痕迹元素。我们将在AHS队列中比较86个事件前列腺癌病例中的这些元素与172个对照（匹配年龄的频率，饮食调查的频率，完成饮食调查以及最近的PSA测试）。我们将使用中子激活分析（NAA）来分析目标的微量元素。我们证明将其他痕量元素视为具有成本效率的假设产生子研究的合理性。 这项试验研究的次要目的是检查脚趾甲中测量的砷和硒的有效性，与在此同类中诊断之前收集的膳食硒和砷农药的标准问卷测量相比。在居住稳定的人群中，痕量元素的生物标志物可以很好地衡量暴露量，从而减少了对农药和复杂食品频率问卷（FFQS）详细列表的问卷的需求。