ENTOMOLOGICAL ASSUMPTIONS OF DENGUE CONTROL

登革热控制的昆虫学假设

• 批准号: 6532739
• 负责人: THOMAS WALLACE SCOTT
• 金额: $ 31.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6532739
• 关键词: Aedes; animal ecology; animal population density; arthropod borne communicable disease; atmosphere /weather; blood chemistry; communicable disease control; communicable disease transmission; computer simulation; data collection methodology /evaluation; dengue; dengue virus; disease /disorder proneness /risk; disease vectors; enzyme linked immunosorbent assay; field study; human subject; questionnaires; statistics /biometry

DESCRIPTION (Adapted from the applicant's Abstract): Since the abandonment of Aedes aegypti eradication efforts in the late 1960's, the goal of dengue control programs has been to prevent severe forms of disease (DHF/DSS) by reducing mosquito vector populations to levels that significantly lower, but do not eliminate virus transmission. This strategy assumes a quantitative relationship between mosquito densities and intensity of dengue transmission which has never been tested. The objective of this project is to determine the nature of that relationship. That is, to measure directly dengue transmission rates after lowering mosquito population densities to levels between minimum (elimination) and maximum (no effect) thresholds. We will use traditional and novel entomological surveillance techniques to monitor mosquito populations and measure serological conversion against dengue viruses in cohorts of Peruvian school children as an index of dengue transmission. We will characterize the relationship between Ae. aegypti abundance and dengue seroconversion rates with multiple logistic regression analyses. Using entomological data on container type and indices of adult mosquito density and seroprevalence data, we will parameterize a dengue computer simulation model that integrates site specific information on mosquitoes with human age structure, human seroprevalence rates, and weather data. Using the model, we will estimate mosquito density thresholds and the effects of mosquito population reductions on dengue risk. Because, nearly all factors influencing dengue transmission are believed to vary spatially, all data gathered in our study will be indexed geographically. We will use kriging techniques to characterize spatial patterns in parameters and to develop interpolated maps for mosquito abundance and dengue risk. The first 2 years of our study will be devoted to gathering entomological and serological data, indexing geographic information, and characterizing the existing spatial patterns of mosquito abundance and dengue transmission. During subsequent years, we will quantify the effects of vector control interventions on incidence of infection. Our study will (1) be the first to test directly the entomological thresholds of dengue transmission, (2) be the first to examine empirically the relationship between mosquito density and dengue virus transmission, and (3) have direct application to control of dengue worldwide.

描述（改编自申请人的摘要）：自放弃以来 1960 年代末根除埃及伊蚊的努力，登革热的目标 控制计划的目的是通过以下方式预防严重疾病（DHF/DSS）： 将蚊媒种群减少到显着降低的水平，但是 不能消除病毒传播。 该策略假设定量 蚊子密度与登革热传播强度之间的关系 从未被测试过。 该项目的目标是确定 这种关系的性质。 即直接测量登革热 将蚊子种群密度降低到一定水平后的传播率 介于最小（消除）和最大（无影响）阈值之间。 我们将 使用传统和新颖的昆虫学监测技术来监测 蚊子种群并测量针对登革热的血清学转化 秘鲁学童群体中的病毒作为登革热指数 传播。 我们将描述 Ae 之间的关系。埃及伊蚊 通过多元逻辑回归分析丰度和登革热血清转化率 分析。 利用有关容器类型和成虫指数的昆虫学数据 蚊子密度和血清流行率数据，我们将参数化登革热 计算机模拟模型，集成了站点特定信息 蚊子与人类年龄结构、人类血清流行率和天气的关系 数据。 使用该模型，我们将估计蚊子密度阈值和 蚊子数量减少对登革热风险的影响。 因为，几乎 据信影响登革热传播的所有因素都在空间上有所不同， 我们研究中收集的所有数据都将按地理索引。 我们将使用 克里格技术来表征参数的空间模式并 绘制蚊子丰度和登革热风险的插值图。 第一个 我们的两年学习将致力于收集昆虫学和 血清学数据，索引地理信息，并表征 蚊子丰度和登革热传播的现有空间模式。 在接下来的几年中，我们将量化病媒控制的效果 对感染发生率的干预措施。 我们的研究将 (1) 第一个 直接测试登革热传播的昆虫学阈值，(2) 第一个凭经验检验蚊子密度之间的关系 和登革热病毒传播，并且（3）可直接应用于控制 全世界登革热。

项目成果

Incomplete Protection against Dengue Virus Type 2 Re-infection in Peru.

秘鲁对 2 型登革热病毒再次感染的保护不完善。

• 发表时间: 2016-02
• 影响因子: 3.8
• 作者: Forshey, Brett M;Reiner, Robert C;Olkowski, Sandra;Morrison, Amy C;Espinoza, Angelica;Long, Kanya C;Vilcarromero, Stalin;Casanova, Wilma;Wearing, Helen J;Halsey, Eric S;Kochel, Tadeusz J;Scott, Thomas W;Stoddard, Steven T
• 通讯作者: Stoddard, Steven T

Temporal and geographic patterns of Aedes aegypti (Diptera: Culicidae) production in Iquitos, Peru.

秘鲁伊基托斯埃及伊蚊（双翅目：蚊科）生产的时间和地理格局。

• 发表时间: 2004-11
• 影响因子: 2.1
• 作者: Morrison, Amy C;Gray, Kenneth;Getis, Arthur;Astete, Helvio;Sihuincha, Moises;Focks, Dana;Watts, Douglas;Stancil, Jeffrey D;Olson, James G;Blair, Patrick;Scott, Thomas W
• 通讯作者: Scott, Thomas W

Performance of the tourniquet test for diagnosing dengue in Peru.

在秘鲁进行用于诊断登革热的止血带测试。

• 发表时间: 2013-07
• 作者: Halsey, Eric S;Vilcarromero, Stalin;Forshey, Brett M;Rocha, Claudio;Bazan, Isabel;Stoddard, Steven T;Kochel, Tadeusz J;Casapia, Martin;Scott, Thomas W;Morrison, Amy C
• 通讯作者: Morrison, Amy C

Adult size and distribution of Aedes aegypti (Diptera: Culicidae) associated with larval habitats in Iquitos, Peru.

与秘鲁伊基托斯幼虫栖息地相关的埃及伊蚊（双翅目：蚊科）成虫大小和分布。

• 发表时间: 2004-07
• 影响因子: 2.1
• 作者: Schneider, Jennifer R;Morrison, Amy C;Astete, Helvio;Scott, Thomas W;Wilson, Mark L
• 通讯作者: Wilson, Mark L

Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission.

1999 年至 2005 年秘鲁伊基托斯登革热病毒的流行病学：流行期间和流行期间的传播模式。

• 发表时间: 2010
• 影响因子: 3.8
• 作者: Morrison, Amy C;Minnick, Sharon L;Rocha, Claudio;Forshey, Brett M;Stoddard, Steven T;Getis, Arthur;Focks, Dana A;Russell, Kevin L;Olson, James G;Blair, Patrick J;Watts, Douglas M;Sihuincha, Moises;Scott, Thomas W;Kochel, Tadeusz J
• 通讯作者: Kochel, Tadeusz J