Social Cognition and Human Orbital Prefrontal Cortex

社会认知和人类眼眶前额叶皮层

• 批准号: 6771035
• 负责人: Robert Thomas Knight
• 金额: $ 15.2万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-02 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6771035
• 关键词: behavioral /social science research tag; bias; brain injury; clinical research; cognition; decision making; emotions; gamblings; high risk behavior /lifestyle; human subject; magnetic resonance imaging; neural information processing; neuroanatomy; neuropsychological tests; neuropsychology; patient oriented research; perception; prefrontal lobe /cortex; questionnaires; social adjustment; social behavior; statistics /biometry; stroke

DESCRIPTION (provided by applicant): This proposal is designed to further our understanding of the contribution of the orbital prefrontal cortex (PFCx) to human social behavior. Techniques drawn from cognitive neuroscience will be used in an effort to integrate information processing theories of social adjustment with theories of emotional influences on cognition. Neuropsychological and high field functional neuroimaging (4T) approaches will be employed to examine the contribution of orbital PFCx to the interplay of emotional response on two on-line predictors of social adjustment: decision making and judgment of social stimuli. Neuropsychological studies in patients with discrete damage in orbital PFCx examine the involvement of this region in emotional biasing of social decisions and judgments. Functional neuroimaging studies in healthy controls will assess whether there is evidence of activation in orbital PFCx in these tasks. The experimental approach is designed to provide converging lesion and fMRI information on the role of orbital PFCx in social behavior. The proposed research draws on paradigms for eliciting emotion and examining decisions and judgments that have been used extensively in previous research. Well-validated tasks assessing risky decisions and judgments of social behavior that are susceptible to emotional bias will also be implemented. Risky decision making will be assessed using the Perceptions of Risk Questionnaire and a roulette gambling task. Judgments of social behavior will be assessed using the Profile of Nonverbal Sensitivity and the Pictures of Facial Affect Set. The proposed research represents a novel application of these paradigms because previous studies have not attempted to systematically relate these processes to activity in brain areas felt to be implicated in social adjustment. The proposal is designed to provide a basis for developing a larger program of research aimed at understanding the neural basis of social behavior.

描述（由申请人提供）：该提案旨在进一步理解轨道前额叶皮层（PFCX）对人类社会行为的贡献。从认知神经科学中提取的技术将用于将社会调整的信息处理理论与情感影响理论相结合。将采用神经心理学和高场功能神经影像学（4T）方法来研究轨道PFCX对情感反应相互作用的贡献，即社会调整的两个在线预测指标：对社会刺激的决策和判断。轨道PFCX中离散损害患者的神经心理学研究检查了该地区对社会决策和判断的情感偏见的参与。健康对照中的功能神经影像学研究将评估这些任务中轨道PFCX激活的证据。实验方法旨在提供有关轨道PFCX在社会行为中作用的融合病变和fMRI信息。拟议的研究借鉴了引起情绪并检查在先前研究中广泛使用的决策和判断的范式。还将实施精心验证的任务，以评估容易受到情感偏见的社会行为的危险决策和判断。风险决策将使用对风险问卷和轮盘赌博任务的看法进行评估。将使用非语言敏感性和面部影响集的图片来评估社会行为的判断。拟议的研究代表了这些范式的新应用，因为以前的研究并未尝试将这些过程与大脑区域的活动联系起来，这被认为与社会调整有关。该提案旨在为制定旨在理解社会行为神经基础的更大研究计划提供基础。