Sleep Heart Health Study

睡眠心脏健康研究

• 批准号: 6822180
• 负责人: JOHN A ROBBINS
• 金额: $ 8.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6822180
• 关键词: cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; cooperative study; coronary disorder; data collection methodology /evaluation; functional ability; human morbidity; human mortality; human subject; hypertension; information dissemination; longitudinal human study; polysomnography; quality of life; respiratory airflow disorder; sleep apnea; sleep disorders; stroke

DESCRIPTION (provided by applicant): The prevalence of sleep disordered breathing (SDB) in middle aged persons in the general population is estimated to be 4 percent in men and 2 percent in women with higher rates observed in the elderly. Accumulating evidence from retrospective and cross-sectional studies suggest that SDB is associated with the presence of cardiovascular and cerebrovascular disease (CVD) and consequent increased mortality and morbidity. However, there is little prospective data indicating whether SDB is an independent risk factor for the development of DVD. The Sleep Heart Health Study (SHHS) is a longitudinal multi-center cohort study that was started in 1994 to determine the cardiovascular consequences of SDB. Initially, SHHS recruited 6,441 participants (1996-98) to undergo in-home polysomnography (PSG) and acquisition of other CVD and sleep-related data. A repeat examination with repeat PSG (2001-2003) has just been completed. Mortality and morbidity follow-up is ongoing, but event rates have been insufficient to provide stable estimates of the effect of SDB on incident CVD and mortality. Additionally, a unique resource of SHHS is its archive of approximately 10,000 PSGs, associated scoring and clinical covariate data. Providing the scientific community access to this data has always been an important goal of SHHS and has the potential to realize significant benefits in collaborative research ranging from novel methods of signal processing to identifying unique epidemiologic associations. Therefore, this application proposes additional mortality and morbidity follow-up of the SHHS cohort, continuation of longitudinal and cross-sectional data analyses focused on SDB as a risk factor for cardiovascular events and hypertension, and development of an infrastructure to facilitate access by the general scientific community to the SHHS PSG archive. These goals will be achieved by accomplishing the following specific aims: 1) to continue follow-up of the SHHS cohort in order to assess SDB as a risk factor for new-onset hypertension and new-onset and recurrent cardiovascular disease; 2) to characterize the natural history of SDB and determine how change in RDI is related to risk for interim and incident CVD events; 3) to characterize the relationship between SDB and SDB progression with quality of life, daytime sleepiness and motor vehicle accidents; 4) to use the PSG data as well as previous collected risk factor data from parent cohorts to develop a clinically and epidemiologically applicable model of risk relating to SDB; and 5) to develop an infrastructure to facilitate data sharing, collaborative analysis and dissemination of data analytic tools and research findings to the scientific community. Accomplishing these goals will provide important information concerning the public health impact of SDB

描述（由申请人提供）：普通人群中中年患者的睡眠失调呼吸（SDB）的患病率估计为男性为4％，在老年人中观察到较高率的女性中，男性为2​​％。回顾性和横截面研究中积累的证据表明，SDB与心血管和脑血管疾病（CVD）的存在有关，因此死亡率和发病率增加。但是，几乎没有前瞻性数据表明SDB是否是开发DVD的独立危险因素。 Sleep Heart Health研究（SHHS）是一项纵向多中心队列研究，于1994年开始，以确定SDB的心血管后果。最初，SHHS招募了6,441名参与者（1996 - 98年），进行了家庭多摄影术（PSG）并获取其他CVD和与睡眠有关的数据。重复PSG（2001-2003）的重复检查刚刚完成。死亡率和发病率随访正在进行中，但是事件速率不足以对SDB对事件CVD和死亡率的影响提供稳定的估计。此外，SHHS的独特资源是其大约10,000 psg的档案，相关的评分和临床协变量数据。提供科学社区访问这些数据一直是SHHS的重要目标，并有可能在合作研究中实现重大好处，从新颖的信号处理方法到确定独特的流行病学关联。因此，该应用程序提出了SHHS队列的额外死亡率和发病率随访，延续和横断面数据分析的延续集中在SDB上，这是心血管事件和高血压的危险因素，以及开发基础设施，以促进一般科学界向SHHS PSG Archive访问一般科学界。这些目标将通过实现以下特定目的来实现：1）继续对SHHS队列进行后续措施，以评估SDB作为新发育高血压以及新发育和复发性心血管疾病的危险因素； 2）表征SDB的自然历史并确定RDI中的变化与中期和事件CVD事件的风险有关； 3）表征SDB和SDB发展与生活质量，白天嗜睡和机动车事故之间的关系； 4）使用PSG数据以及先前从父群体收集的风险因素数据来开发与SDB有关的临床和流行病学上适用的风险模型； 5）开发基础架构，以促进数据分析工具和研究结果的数据共享，协作分析和分发给科学界。实现这些目标将提供有关SDB公共卫生影响的重要信息