CARDIOVASCULAR CONSEQUENCES OF SLEEP APNEA

睡眠呼吸暂停对心血管的影响

• 批准号: 2519474
• 负责人: JOHN A ROBBINS
• 金额: $ 12.99万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519474
• 关键词: age difference; cardiovascular disorder; cardiovascular disorder epidemiology; cooperative study; data collection; disease /disorder proneness /risk; gender difference; human subject; oximetry; patient monitoring device; polysomnography; racial /ethnic difference; sleep apnea; sleep disorders

The aim of this multicenter observational study is to determine the prevalence of and the degree to which sleep apnea is an independent or contributing risk factor for the development of cardiovascular or cerebrovascular disease. This application is for a Clinical Center. It is a joint proposal from Cardiovascular Health Study (CHS) at the University of California Davis and the University of Pittsburgh. The population from which participants will be selected includes 2,80& individuals over the age of 66. African Americans make up 20% of the age and gender stratified cohort. Well defined cardiovascular disease prevalence data has been gathered for more than 5 years on most of the cohort. This will allow the identification true incident events. Approximately 1 ,000 study participants will be recruited from the CHS cohort, allowing for stratification by age, race, and gender. Standardized baseline measures of all major cardiovascular risk factors have been obtained. Objective measures of sleep disorders will be gathered in 3 stages: 1) nocturnal pulse oximetry to detect repetitive oxygen desaturation in all participants, 2) eight channel home monitoring of sleep for all those with positive stage 1 tests, and 3) full polysomnography in a local sleep laboratory for a small subset of those with positive stage 2 results. Participants will be closely followed for at least 5 years for cardiovascular morbidity and mortality by CHS. All baseline and follow-up results will be sent to a Data Coordinating Center for analyses.

这项多中心观察研究的目的是确定 睡眠呼吸暂停的患病率和程度是独立的或 造成心血管发展的危险因素 脑血管疾病。此应用程序用于临床中心。这是 大学心血管健康研究（CHS）的联合建议 加利福尼亚戴维斯和匹兹堡大学人口来自 选择哪些参与者包括2,80个和个人 66岁。非洲裔美国人占年龄的20％，性别分层 队列。定义明确的心血管疾病患病率数据已经 在大多数队列中聚集了5年以上。这将允许 识别真实事件事件。大约1,000个研究 参与者将从CHS队列招募，允许参与者 按年龄，种族和性别分层。 标准化的基线度量 在所有主要的心血管危险因素中。客观的 睡眠障碍的度量将分为3个阶段：1）夜间 脉搏血氧蛋白法以检测所有重复的氧气去饱和 参与者，2）所有患有所有患者 正阶段1测试，3）当地睡眠中的完整多聚疗法 一小部分具有阳性2阶段结果的实验​​室。 参与者将至少遵循5年 CHS的心血管发病率和死亡率。 所有基线和随访 结果将发送到数据协调中心进行分析。