Stress-reduction in African Americans with metabolic syn

通过代谢综合征减轻非裔美国人的压力

• 批准号: 6967518
• 负责人: YUN MENG
• 金额: $ 4.64万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-10-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6967518
• 关键词: African American; adult human (21+); alternative medicine; behavioral /social science research tag; biomarker; cardiovascular disorder risk; cardiovascular function; cooperative study; coping; cortisol; cytokine; glucose metabolism; health education; human subject; human therapy evaluation; inflammation; insulin sensitivity /resistance; meditation; metabolic syndrome; oxidative stress; patient oriented research; psychological adaptation; psychological stressor; quality of life; stress management; vascular resistance

Although the etiology of the metabolic syndrome (MetS) is complex, psychological stress appears to play an important role, possibly through inflammatory response and other metabolic and hormonal abnormalities. A major consequence of MetS leading to increased cardiovascular risk is endothelial dysfunction, a condition which is also influenced by psychological stress. Previous controlled clinical studies have shown that mind-body interventions for stress reduction, particularly Transcendental Meditation (TM), are effective in reducingpsychological stress and a number of cardiovascular disease (CVD) risk factors, as well as intermediate and clinical cardiovascular endpoints in AAs and Whites. It is therefore likely that TM is also beneficial in reducing adverse consequences of MetS leading to cardiovascular risk, including endothelial dysfunction, inflammation and metabolic abnormalities. These effects, however, have never been evaluated. Project IIIB Primary Aim: To evaluate the effect of a stress reduction intervention using transcendental meditation (TM) on vascular function in a sample of community individuals with the metabolic syndrome (MetS). We will compare changes in endothelial function, assessed by means of brachial artery flow-mediated dilation (FMD), before and after intervention between two randomized intervention groups: TM plus health education (HE), and HE alone. As a secondary endpoint, we will examine arterial stiffness, measured using pulse-wave velocity methodology. Project IIIB Secondary Aim #1: To evaluate the effect of TM on metabolic and other biochemical abnormalities associated with the MetS. We will compare a number of inflammatory and oxidative stress markers, adipocytokines, and indices of glucose metabolism and insulin resistance between the two randomized groups before and after the intervention. These biomarkers have been related to the MetS and CVD risk, or are likely to be influenced by stress. Project IIIB Secondary Aim #2: To evaluate the effect of TM on improving psychological well-being, including reducing perceived stress, depressive symptoms, anger and hostility. The effect of TM on reducing urinary cortisol level as a measure of stress-induced hypothalamic-pituitary-adrenal axis activation will be studied.

尽管代谢综合征 (MetS) 的病因很复杂，但心理压力似乎发挥着重要作用，可能是通过炎症反应和其他代谢和激素异常引起的。 MetS 导致心血管风险增加的一个主要后果是内皮功能障碍，这种情况也受到心理压力的影响。先前的对照临床研究表明，用于减轻压力的身心干预措施，特别是先验冥想（TM），可以有效减少心理压力和许多心血管疾病（CVD）危险因素，以及中间和临床症状。 AA 和白人的心血管终点。因此，TM 也可能有利于减少 MetS 导致心血管风险的不良后果，包括内皮功能障碍、炎症和代谢异常。然而，这些影响从未得到评估。 项目 IIIB 主要目标：评估使用先验冥想 (TM) 进行减压干预对患有代谢综合征 (MetS) 的社区个体样本中血管功能的影响。我们将比较两个随机干预组（TM 加健康教育（HE）和单独 HE）干预前后内皮功能的变化，通过肱动脉血流介导的扩张（FMD）进行评估。作为次要终点，我们将检查使用脉搏波速度方法测量的动脉僵硬度。 项目 IIIB 次要目标 #1：评估 TM 对代谢和其他生化的影响 与 MetS 相关的异常。我们将比较干预前后两个随机组之间的一些炎症和氧化应激标志物、脂肪细胞因子以及葡萄糖代谢和胰岛素抵抗指标。这些生物标志物与 MetS 和 CVD 风险相关，或者可能受到压力的影响。 项目 IIIB 次要目标 #2：评估 TM 对改善心理健康的效果，包括减少感知压力、抑郁症状、愤怒和敌意。将研究 TM 对降低尿皮质醇水平的影响，作为压力诱导的下丘脑-垂体-肾上腺轴激活的衡量标准。