Ischemia Induced Plasticity - Implications for Therapy

缺血引起的可塑性 - 对治疗的影响

• 批准号: 6780361
• 负责人: JOEL H GREENBERG
• 金额: $ 30.12万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780361
• 关键词: behavior test; behavioral /social science research tag; brain circulation; brain injury; brain metabolism; cerebral ischemia /hypoxia; disease /disorder model; functional ability; glucose metabolism; laboratory rat; medical rehabilitation related tag; neural plasticity; paired stimuli; rehabilitation; somesthetic sensory cortex; stroke; vibrissae

DESCRIPTION (provided by applicant): There is an evolving understanding that neuronal cortical connections can be altered and remodeled following injury to the central nervous system. Humans with stroke frequently show recovery of function that seems to be correlated with activation of regions both in the peri-infarct zone as well as in the hemisphere opposite to the stroke. Cerebral ischemic injury in animals is accompanied by hyperexcitability in tissue surrounding the ischemic core and frequently in homologous regions of the contralateral cortex. There is clinical and behavioral data showing that the degree of recovery can be altered using sensory augmentation including enriched environments and task-specific training. Recovery following chronic stroke can also be improved with pharmacological treatment, with the recovery dependent on activity during treatment. We will use hemodynamic image mapping to examine the reorganization of the brain following a focal cerebral ischemic insult and correlate this reorganization with behavioral recovery. Focal ischemia/reperfusion will be achieved using a compression model that results in ischemic damage confined to the posteriomedial barrel subfield of the first somatosensory cortex of the rat, and reorganization will be evaluated by examining the changes in the blood flow response maps to vibrissae stimulation. The mystacial vibrissae of the rat, with their corresponding representation in the somatosensory cortex, provides an ideal vehicle for studies dealing with damage and subsequent recovery in the central nervous system. Examination of how the brain reorganizes following ischemia/reperfusion to the rat barrel somatosensory cortex, as opposed to ablative injury, will provide valuable information about strategies for improving recovery following stroke. Strategies for altering reorganization of blood flow and metabolism that will be examined include administration of pharmacological agents and stromal cell, as well as targeted sensory augmentation.

描述（由申请人提供）：有一种不断发展的理解，即在中枢神经系统受伤后可以改变和重塑神经元的皮质连接。中风的人经常显示功能的恢复，这似乎与侵入周围区域以及与中风相对的半球的区域激活相关。动物的脑缺血性损伤伴随着缺血性核心周围组织的过度兴奋性，并且经常在对侧皮质的同源区域中。有临床和行为数据表明，使用感官增强（包括丰富的环境和特定于任务的训练）可以改变恢复程度。慢性中风后的恢复也可以通过药理治疗来改善，其恢复取决于治疗过程中的活动。我们将使用血液动力学图像映射来检查局灶性脑缺血性损伤后大脑的重组，并将这种重组与行为恢复相关联。使用压缩模型将实现局灶性缺血/再灌注，该模型将局限于大鼠的第一个体感皮质的后体枪管子场，并通过检查血流反应映射对颤音刺激的血液流动反应图的变化来评估重组。大鼠的神秘颤音及其在体感皮层中的相应表示，为研究中枢神经系统中的损伤和随后恢复的研究提供了理想的工具。检查大脑如何重组以下缺血/再灌注对大鼠桶体感皮质而不是消融性损伤，将提供有关改善中风后恢复恢复的策略的宝贵信息。将研究将研究血流和代谢的重组的策略，包括药理学剂和基质细胞的施用以及靶向的感觉增强。