PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II

肺栓塞 DX-II 的前瞻性研究

• 批准号: 6659858
• 负责人: Pamela K Woodard
• 金额: $ 1.54万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659858
• 关键词: angiography; bioimaging /biomedical imaging; clinical research; clinical trials; computed axial tomography; cooperative study; diagnosis design /evaluation; human subject; lung imaging /visualization /scanning; noninvasive diagnosis; pulmonary circulation obstruction; ultrasonography; venous thrombosis

(Adapted from the applicant's abstract) This is a multicenter collaborative study to determine the sensitivity, specificity, positive and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Spiral CT is a nearly noninvasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Even though spiral CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test. This could lead to overtreatment or undertreatment, both of which have serious potential complications. The role of spiral CT in the diagnosis of PE requires an accurate evaluation which will be made in this investigation by a composite of diagnostic tests including pulmonary angiography, ventilation/perfusion lung scans, venous compression ultrasound, and outcome analysis. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from underdiagnosis and major bleeding from overdiagnosis; 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability; 3) the protocol parallels standard diagnostic strategy without subjecting the patients to risk entirely for the acquisition of data and 4) the team of investigators is strong and has collaborated previously in successful research in PE.

（根据申请人的摘要改编）这是一项多中心协作研究，旨在确定对比度的敏感性，特异性，正面和负面预测值增强了螺旋计算机断层扫描（螺旋CT），用于诊断急性肺栓塞（PE）。 肺栓塞很常见，但经常未被诊断和致命。 螺旋CT是一项几乎无创的测试，通过在肺动脉中显示血栓的轮廓，提供了对PE进行明确诊断的可能性。 但是，其在PE诊断中的效用尚不清楚。 即使螺旋CT尚未得到充分验证，许多医院的医生现在将其用作确定的唯一诊断测试。 这可能导致过度治疗或不足，两者都有严重的潜在并发症。 螺旋CT在PE诊断中的作用需要进行准确的评估，这将在本研究中通过诊断测试（包括肺部血管造影，通风/灌注肺扫描，静脉压缩超声和结果分析）进行研究。 该提议的优势是：1）PE问题在诊断不足和因过度诊断而大量出血的生活方面的重要性； 2）一种新技术在诊断PE的潜在适用性，该技术将广泛可用； 3）协议与标准诊断策略相似，而无需使患者完全冒着数据的风险，而4）调查人员团队很强，并且曾在PE的成功研究中合作。