MRS TO MONITOR GLUCURONIDASE ACTIVITY IN CYSTIC FIBR SLY DISEASE & GENE THER

MRS 监测囊性纤维病中的葡萄糖醛酸酶活性

• 批准号: 6495450
• 负责人: JERRY D GLICKSON
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495450
• 关键词: animal tissue; bioimaging /biomedical imaging; biomedical resource; connective tissue; human tissue; magnetic resonance imaging; medical rehabilitation related tag; radiology; rehabilitation; skeletal system

In animal models articular cartilage has been demonstrated to change in thickness and volume during extended periods of non-weight bearing. An accurate and reproducible magnetic resonance imaging method of non-invasively quantitating articular cartilage volumes has been developed and validated. We are using this method to follow the volume of the patellar articular cartilage in patients with recent ankle fractures who are non-weight bearing in that lower extremity. Cartilage volumes are measured on the day of the initial hospital visit and at intervals through their course of healing and recovery.

在动物模型中，关节软骨已被证明 长时间非重量期间厚度和体积的变化 轴承。 准确且可重复的磁共振成像 非侵入性定量关节软骨体积的方法 已被开发和验证。 我们使用这种方法来遵循 近期接受过膝关节置换手术的患者髌骨关节软骨体积 下肢不承重的踝关节骨折。 软骨体积是在初次住院当天测量的 并定期拜访他们的康复过程。